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Pronunciation: “ah-FIN-eh-tour” (“ev-eh-ROLE-lee-mus”)

Disclaimer: This patient information sheet summarizes the information about everolimus as prescribed for treatment of advanced kidney cancer and is not meant to substitute for medical advice. If you would like more information, talk with your healthcare team. Every patient is different, and only you and your doctor can decide the best treatment plan for you. Please see our guide on talking to your doctor about treatments for kidney cancer.


Patient Assistance Programs (PAP) are financial programs to help cover costs of medical tests and treatments. They are usually offered by drug manufacturers but can also be through individual hospitals, local governments, and private organizations, and each PAP will have different benefits and enrollment requirements and forms.  Don’t let the paperwork stop you from getting the help you need and contact the KCA if you need help understanding your options.Patient Assistance Program
Patient Assistance Now Oncology (PANO)

What type of drug is it?: Targeted therapies (some also referred to as TKIs) are drug treatment that work to slow or stop cancer cells from growing by blocking pathways your tumor cells use to grow and spread.Targeted therapy (also referred to as an mTOR inhibitor).

How is it prescribed?:  Everolimus is approved to be used alone (as a single agent) or in combination with lenvatinib (Lenvima).

How is it administered?:  Everolimus is a tablet taken by mouth at the same time every day (with or without food).

Do NOT crush or break tablets before taking. If you are unable to swallow the tablets, notify your healthcare provider for further instructions.

How often do I take it?:  Everolimus is taken once a day, around the same time. If you miss a dose, please call your healthcare provider for guidance on how to proceed.

When taking in combination with another drug, please see the separate sheet on lenvatinib for its dosing information.

Storage: Tablets should be stored in a safe place (away from children) where they will be kept dry, avoiding exposure to extreme hot or cold temperatures.

Restrictions:  Grapefruit (including all supplements and foods containing grapefruit or grapefruit juice) and St. John’s Wort (also called Hypericum perforatum) may increase the amount of this medication in your body and should be avoided.

Vaccinations may not work as well when being treated with everolimus. You should contact your doctor before receiving any vaccine and avoid being around people who have received a live vaccine.

Please see our guide on what to ask and tell your doctor before starting any medication.

Side Effects:   There can be a range of side effects for any medication. Letting your doctor know about these side effects does not mean you have to stop treatment – but may mean that your treatment needs to be adjusted. Therefore, it is important to let your doctor know if you are experiencing side effects so they can manage your medications appropriately. Please see our educational sheet on side effects for more information on what to watch out for and how to talk with your doctor should you experience any of them.

Revised May 2022
Adapted from the package insert. Novartis Pharmaceuticals Corporation, February 2022