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Lenvima® (lenvatinib) + Afinitor® (everolimus) for Kidney Cancer

Lenvima is a medication used in combination with everolimus for the treatment of patients with advanced renal cell carcinoma (RCC) following one prior anti-angiogenic therapy. Refer to the Afinitor drug sheet for further information.  

Daily dose is:
18 mg Lenvima = (1) 10 mg tablet and (2) 4 mg tablets 
5 mg Afinitor = (1) 5 mg tablet

Afinitor
How supplied: 5 mg tablets

Lenvima:
How supplied:  4mg, 10mg, capsule 
Storage:   Room temperature
Route of Administration:  Lenvima is a capsule(s) taken by mouth
Schedule:   Once a day. 

How should I take Lenvima?

  • Take it exactly the way your healthcare provider tells you
  • Take it at the same time each day until disease progression or until unacceptable toxicity.
  • If a dose is missed and cannot be taken within 12 hours, skip that dose and take the next dose at the usual time of administration.
  • Alternatively, the capsules can be dissolved in a small glass of liquid.      
  • Measure 1 tablespoon of water or apple juice and put the capsules into the liquid without breaking or crushing them. Leave the capsules in the liquid for at least 10 minutes. Stir for at least 3 minutes. drink the mixture. After drinking, add the same amount (1 tablespoon) of water or apple juice to the glass. Swirl the contents a few times and swallow the additional liquid.

Dietary restrictions: Can be taken with or without food

What is the most important information I should know about Lenvima?

  • Lenvima can cause serious liver problems including death. 

Tell your healthcare provider right away if you have any of these signs of liver problems: 

  • yellowing of your skin or the whites of your eyes (jaundice)
  • dark urine
  • tiredness 
  • nausea or vomiting
  • loss of appetite
  • pain on the right side of your abdomen
  • increased bruising

What is the most important information I should know about Lenvima?

  • Lenvima can cause blood clots. 

Tell your healthcare provider right away if you experience any of these problems: 

  • severe chest pain or pressure
  • pain in your arms, back, neck or jaw
  • shortness of breath
  • numbness or weakness on one side of your body
  • trouble talking
  • sudden severe headache
  • sudden vision changes

I should tell my healthcare provider if I have: 

  • Hypertension: Goal is to control blood pressure prior to treatment
  • Have any other medical conditions

For females, tell your doctor if you:

  • Are pregnant or plan to become pregnant. Taking Lenvima during pregnancy may cause the death of an unborn baby or birth defects. You should not become pregnant while you are taking Lenvima. Talk to your doctor if you are pregnant or plan to become pregnant.
  • Are able to become pregnant. You should use effective birth control during your treatment with Lenvima. Talk to your doctor about birth control methods to prevent pregnancy while you are talking Lenvima.
  • Discontinue breast-feeding 

For males:

  • Lenvima may result in damage to male reproductive tissues leading to reduced fertility of unknown duration.

Tell your healthcare provider at each visit about all the medications you take including prescription and non-prescription medicine, vitamins, and herbal supplements. Lenvima may affect the way other medicines work and other medicines may affect how Lenvima works. 

Ask your doctor or pharmacist if you are not sure if your medicine is one listed above. If you are taking any medicines for the conditions listed above, your doctor might need to prescribe a different medicine or your dose of Lenvima may need to be changed. Talk with your doctor before you start taking any new medicine. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

What are the possible side effects of Lenvima?

Common Side effects include:

  • diarrhea
  • high blood pressure  
  • fatigue
  • constipation
  • muscle or joint aches
  • decreased appetite
  • weight decrease
  • nausea
  • stomatitis/oral inflammation
  • peripheral edema
  • cough
  • abdominal pain
  • dyspnea
  • rash
  • protein in the urine

Notify your health care provider Tell your health care provider right away if you have any of the following symptoms: your skin or the white part of your eyes turns yellow (jaundice); dark, “tea-colored” urine; light-colored bowel movements. 

These are not all of the possible side effects of Lenvima. Tell your healthcare provider if you have any side effects that bother you or that do not go away.   

Call your doctor for medical advice about side effects. For more information, ask your healthcare provider or pharmacist.  

Lenvima may cause serious side effects including:

  • high blood pressure
  • heart problems: decreased ejection fraction or heart failure
  • irregular or fast heartbeat or fainting
  • blood clots
  • changes in kidney function

General information about Lenvima: Medicines are sometimes prescribed for purposes other than those listed in a patient information leaflet. Do not use Lenvima for a condition for which it was not prescribed. Do not give Lenvima to other people, even if they have the same symptoms you have. It may harm them.

This patient information sheet summarized the most important information about Lenvima. If you would like more information, talk with your doctor. You can ask your doctor or pharmacist for information about Lenvima that is written for healthcare professionals.  

Patient Assistance Program:  

Phone: 1-866-61-EISAI (1-866-613-4724)
Fax: 1-855-246-5192
Hours: 9 AM to 6 PM ET, Monday through Friday
www.LenvimaReimbursement.com 

Resources:  Call 1-877-873-4724 or www.Lenvima.com

Adapted from the Lenvima package insert. www.lenvima.com/hcp  September 2019 

KCA disclaimer statement: you should rely primarily upon your doctor for medical information.

www.kidneycancer.org