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Lenvima® (lenvatinib) + Afinitor® (everolimus) for Kidney Cancer

Lenvima is a medication used in combination with everolimus for the treatment of patients with advanced renal cell carcinoma (RCC) following one prior anti-angiogenic therapy. Refer to the Afinitor drug sheet for further information.  

Daily dose is:
18 mg Lenvima = (1) 10 mg tablet and (2) 4 mg tablets 
5 mg Afinitor = (1) 5 mg tablet

Afinitor
How supplied: 5 mg tablets

Lenvima:
How supplied:  4mg, 10mg, capsule 
Storage:   Room temperature in a dry place, do not store in bathroom
Route of Administration:  Lenvima is a capsule(s) taken by mouth
Schedule:   Once a day. 

How should I take Lenvima?

  • Take it exactly the way your healthcare provider tells you
  • Take it at the same time each day
  • May be administered with or without food
  • If a dose is missed and cannot be taken within 12 hours, skip that dose and take the next dose at the usual time of administration.
  • Do not chew or crush. Swallow whole capsule.
  • Alternatively, the capsules can be dissolved in a small glass of liquid. Measure 1 tablespoon of water or apple juice and put the whole capsule into the liquid without breaking or crushing them. Leave the capsules in the liquid for at least 10 minutes. Stir for at least 3 minutes and then drink the mixture. After drinking, add 1 tablespoon of water or apple juice to the glass. Swirl the contents a few times and swallow the additional liquid.

When you start this medication, notify all your healthcare providers such as your primary care doctor, specialists, physical therapists, dentists etc.

Notify your oncologist if you have a heart history such as high blood pressure, heart attack, heart failure or stroke.

What is the most important information I should know about Lenvima?

If you develop a severe allergic reaction such as chest pain, shortness of breath or wheezing, call 911

If you develop an allergic reaction such as rash, hives, itchiness and/ or fevers call your healthcare provider right away.

  • Very serious liver complications can occur while taking this medication. Please notify your healthcare provider immediately if you develop any of the following symptoms:
    • yellowing of your skin or the whites of your eyes (jaundice)
    • dark urine
    • tiredness
    • nausea or vomiting
    • loss of appetite
    • pain on the right side of your abdomen
    • increased bruising
    • light colored stool
  • Severe kidney complications such as the build- up of protein in your urine and urinary tract infections can occur. Please call your healthcare provider if you develop these symptoms:
    • Urinating more often
    • Blood in urine
    • Burning when urinate
    • Unable to urinate
    • Swelling of the face, legs, arms and/or abdomen
    • Foamy urine.
    • Fever of 100.4 or greater
  • You may develop blood clots which can cause heart attacks or stroke. Call your healthcare provider right away if you experience any of these problems:
    • severe chest pain or pressure
    • pain in your arms, back, neck or jaw
    • shortness of breath
    • numbness or weakness on one side of your body
    • trouble talking
    • sudden severe headache
    • sudden vision changes
  • Serious bleeding complications can occur while taking Lenvima. Please call your healthcare provider if you develop the following symptoms:
    • bloody stool
    • tarry stool
    • blood in urine
    • coughing up blood
    • throw up that looks like coffee grinds
    • bleeding gums
    • bleeding nose
    • abnormal bruising
    • feeling dizzy or lightheaded.
  • Lenvima may cause high blood pressure which can cause strokes and heart failure. Please check your blood pressure once a day, every day and notify your healthcare provider if your top number is greater than 150 and/or your bottom number is greater than 90.
  • Irregular heartbeats are known to occur while taking this medication. Notify your healthcare provider if you develop any of the following symptoms:
    • your heart is beating really fast
    • feeling dizzy or wanting to pass out
    • shortness of breath
    • swelling in the legs
  • If you develop any wounds where your skin becomes open, notify your healthcare provider right away. Lenvima will slow down wound healing and can lead to serious skin breakdown.
  • A severe condition called reversible posterior leukoencephalopathy syndrome (RPLS) can occur which causes swelling in your brain. Notify you healthcare provider immediately if you develop any of the following symptoms:
    • headaches
    • vision changes
    • confusion
    • seizures

What are other possible side effects of Lenvima?

Common Side effects include:

  • diarrhea
  • constipation
  • nausea
  • vomiting
  • weight loss
  • taste bud changes
  • mouth sores
  • mouth pain
  • fatigue
  • muscle of joint pain
  • peripheral edema
  • cough
  • abdominal pain
  • dyspnea
  • rash
  • hoarse voice
  • hair loss

Remember, these are not all the possible side effects of Lenvima. Tell your healthcare provider if you have any side effects that bother you and are affecting your quality of life. Do not stop taking this medication until speaking to your healthcare provider for medical advice.  

For females, tell your doctor if you:

  • If you are pregnant or planning to become pregnant, taking Lenvima during pregnancy may cause the death of an unborn baby or birth defects.
  • You should use effective birth control during your treatment with Lenvima. Talk to your doctor about birthcontrol methods to prevent pregnancy while you are talking Lenvima.
  • Discontinue breastfeeding

For males:

  • Lenvima may result in damage to male reproductive tissues leading to reduced fertility of unknown duration.

Tell your healthcare provider at each visit about all the medications you take including prescription and non-prescription medicine, vitamins, and herbal supplements. Lenvima may affect the way other medicines work and other medicines may affect how Lenvima works.

Ask your doctor or pharmacist if you are not sure if your medicine is one listed above. If you are taking any medicines for the conditions listed above, your doctor might need to prescribe a different medicine or your dose of Lenvima may need to be changed. Talk with your doctor before you start taking any new medicine. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

General information about Lenvima: Medicines are sometimes prescribed for purposes other than those listed in a patient information leaflet. Do not use Lenvima for a condition for which it was not prescribed. Do not give Lenvima to other people, even if they have the same symptoms you have. It may harm them.

This patient information sheet summarized the most important information about Lenvima. If you would like more information, talk with your doctor. You can ask your doctor or pharmacist for information about Lenvima that is written for healthcare professionals. 

Patient Assistance Program: 

Phone: 1-866-61-EISAI (1-866-613-4724)
Fax: 1-855-246-5192
Hours: 9 AM to 6 PM ET, Monday through Friday
www.LenvimaReimbursement.com

Resources:  Call 1-877-873-4724 or www.Lenvima.com

Adapted from the Lenvima package insert. www.lenvima.com/hcp, revised December 2020

KCA disclaimer statement: you should rely primarily upon your doctor for medical information.

www.kidneycancer.org