The world's most respected fully accredited kidney cancer charity

Research

We define research as systematic investigation designed to contribute to generalizable knowledge. 

How Does the Kidney Cancer Association (KCA) Promote Research?
We encourage both private and public sector institutions to do more research on kidney cancer. We help researchers in academic medical centers, government, and industry with money and information. We are a catalyst for new ideas. For example, we provide financial grants for basic research into the biology of kidney cancer. KCA members work to raise funds. These competitive awards are made from a pool of funds named in honor of the Association’s late founder, Eugene P. Schonfeld, Ph.D.

KCA funds early-career cancer researchers through its Young Investigator Award (YIA) that provides funding to promising investigators to encourage and promote quality research in urology and clinical oncology. The purpose of this grant is to fund physicians and scientists during the transition from a fellowship program to a faculty appointment. Awards given are based on individual merit and availability of funds. To learn more about the KCA YIA, including the application process, click here.

We are represented in the membership of  the National Cancer Institute’s Renal Cancer Task Force, Biomarkers Consortium, Kidney Cancer SPORE, Cancer Leadership Council, Friends of Cancer Research, and many more collaborations, including our participation in The Cancer Genome Atlas.

Following are examples (the complete list of projects is too long to enumerate here) of Young Investigator Awards and research grants made through your generous contributions to the Eugene P. Schonfeld Fund and monies raised by the Penn State Football Team through “Lift for Life,” its chapter of Uplifting Athletes, and other donors:

Eugene P. Schonfeld Medical Research Awards

ASCO Conquer Cancer Foundation Award
Kathleen M. Mahoney, MD, PhD, Beth Israel Deaconess Medical Center
“PD‐L1 and a secretory variant in Renal Cell Carcinoma”
Mentored by:  Gordon Freeman, PhD

ASCO Conquer Cancer Foundation Award
Eliezer Van Allen, MD, Dana-Farber Cancer Institute
“Dissecting clinical resistance to PI3K inhibitors in PIK3CA or PTEN-mutant cancers.”

Andrew C. Novick & P.H.M. de Mulder / AUA Urology Care Foundation Research Scholar Award
Erik Brincks, PhD, University of Minnnesota, under the mentorship of Thomas S. Griffith, PhD.
“The Influence of Obesity on the Immunotherapy of Renal Cell Carcinoma”

Dana Farber / Harvard Cancer Center Kidney Cancer SPORE Developmental Projects Program
“Evaluating Comparative Effectiveness of Open and Minimally Invasive Kidney Surgery: Patient-Reported Quality-of-Life Outcomes and Cost Effectiveness”

Andrew A. Wagner, MD, Beth Israel Deaconess Medical Center, Assistant Professor of Surgery, Harvard Medical School.  Co-Investigators: Steven Chang MD, BWH; Martin G. Sanda, MD, BIDMC; Su-Chun Cheng, ScD, DFCI; William C. DeWolf, MD, BIDMC; Sarah B. Kim, BA, BIDMC

ASCO Conquer Cancer Foundation Award
Martin Voss, MD,Sloan-Kettering Institute for Cancer Research
“Predictive Tissue Biomarkers for mTOR Inhibitors in Advanced Renal Cell Carcinoma (RCC).”
Mentored by Robert Motzer, MD

ASCO Conquer Cancer Foundation Award
Thai Ho, University of Texas M. D. Anderson Cancer Center
“The role of SETD2, a histone methyltransferase, in the development of renal cell carcinoma” 

Andrew C. Novick, MD and P.H.M. deMulder, MD, AUA Foundation Research Scholar Award
Weijun Liu, PhD, University of Pittsburgh, under the mentorship of James Gnarra, PhD
“VHL Tumor Suppressor and Cell Cycle Regulation”

ASCO Cancer Foundation Young Investigator Award
Aditya Bardia, MD, MPH, Post-doctoral Fellow, Johns Hopkins University
“Evaluation of cardiac glycoside, digoxin, as a novel inhibitor of Hypoxia Inducible Factor-1a and its target genes in tumor microenvironment.”

Dana Farber / Harvard Cancer Center Kidney Cancer SPORE Developmental Projects Program
Steven L. Chang, MD
“Cost Effectiveness Analysis of Routine Percutaneous Renal Biopsy in the Management of Small Renal Masses”

Dana Farber / Harvard Cancer Center Kidney Cancer SPORE Developmental Projects Program
PI: Sabina Signoretti, MD | Co-Investigators: Hans-Olov Adami, MD, PhD & Toni Choueiri, MD
“Clinical, Histological, and Molecular Determinants of Bilateral Renal Cell Cancer”
Andrew C. Novick & P.H.M. de Mulder / AUA Foundation Research Scholar Award
Brian Chapin, MD
M. D. Anderson Cancer Center
“The Endothelial Cell As The Mediator of Angiogenic Escape in Renal Cell Carcinoma”

ASCO Cancer Foundation Young Investigator Award
Stephen Keefe, MD
University of Pennsylvania
“Predicting Response to Antiangiogenic Therapies in Renal Cell Carcinoma”

AUA Foundation Research Scholar Award
David Miller, MD, MPH
UCLA Department of Urology
“Unwarranted Variation in Surgical Treatment of Patients with Early-Stage Kidney Cancer”

ASCO Cancer Foundation Young Investigator Award
Henk Verheul, MD, PhD
Cancer Center at Johns Hopkins
“Combination Antiangiogenesis and Anticoagulatory Therapy in Patients with Advanced Renal Cancer”

ASCO Cancer Foundation Young Investigator Award
Patricia Tang, MD
Princess Margaret Hospital
“The Role of VEGF-A Signalling in Maintenance of the Glomerular Filtration Barrier and Blood Pressure”

P. H.M. de Mulder, MD, AUA Foundation Research Scholar Award
Brian Lane, MD, PhD
Cleveland Clinic Urological Institute
“Molecular Prediction of Kidney Cancer Recurrence after Nephrectomy”

P. H.M. de Mulder, MD, AUA Foundation Research Scholar Award
Stephen Culp, MD, PhD
M. D. Anderson Cancer Center
“Action and Resistance of Targeted Therapy in Non-Clear Cell RCC”

P. H.M. de Mulder, MD, AUA Foundation Research Scholar Award
Kevin Courtney, MD, PhD
Dana-Farber Cancer Institute
“Idenfication of Activators of Phosphoinositide 3-kinase Signaling in Renal Cell Carcinoma as Potential Therapeutic Targets”

P. H.M. de Mulder, MD, ASCO Cancer Foundation Young Investigator Award
Aymen Elfiky, MD, MA
Yale University
“Targeting Phosphoinositide 3-kinase in Renal Cell Cancer”

Joel W. Slaton, MD
Assistant Professor
Department of Urologic Surgery
University of Minnesota
“The Effect of Organ Site on Expression of Progression-Related Genes and Response to Low-Dose Interferon-alpha (IFN-Alpha) Therapy in Renal Cell Carcinoma”

James D. Brooks, MD
Assistant Professor
Department of Urology
Stanford University Medical Center
“Gene Expression Profiling of Renal Cell Carcinoma: A New Cancer Taxonomy”

David A. Stulberg Career Investigator Award
Jared A. Gollob, MD
Associate Director of Biologic Therapy Program
Beth Israel Deaconess Medical Center
“The Effect of Combination Therapy With IL-12 Plus IL-2 on Immune Activation and Antitumor Immunity in Patients with Renal Cell Cancer”

Senior Career Investigator Award
James H. Finke, PhD
Department of Immunology
The Cleveland Clinic Foundation
“Altered T Cell Signaling in Renal Cell Carcinoma”


The Novick research awards are made in memory of our colleague, the late Andrew C. Novick, MD, Chairman of the Cleveland Clinic Glickman Urological and Kidney Institute, who died in 2008 from complications of lymphoma.

The P.H.M. de Mulder research awards are made possible, in part, by a generous contribution to our research endowment from Bayer Shering Pharma in memory of our colleague, P. H.M. de Mulder, MD, who died in 2007 from kidney cancer.

Last Updated on Tuesday, 24, June 2014 13:31