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Cabometyx® (cabozantinib) for advanced kidney cancer

Cabometyx is a medication used to treat advanced kidney cancer in adults

Dosage:  60mg once a day
How supplied: 20mg, 40mg and 60mg tablets  
Storage: Store at room temperature.   
Route of Administration: Cabometyx is a tablet taken by mouth.
Schedule:  Once a day

How should I take Cabometyx?

  • Take it exactly as your healthcare provider tells you
  • Do not take with food. Take at least 1 hour before or at least 2 hours after eating
  • Swallow tablets whole with a full glass (8oz) of water.
  • Do not crush tablets
  • If you miss a dose, and your next dose is in:
    • Less than 12 hours take your next dose at the normal time. Do not make up missed dose.
    • 12 hours or more, take the missed dose as soon as you remember. Take your next dose at the normal time.

What should I avoid while taking Cabometyx:

  • Do not drink grapefruit juice, eat grapefruit or take supplements containing grapefruit during your treatment with Cabometyx. 

When you start this medication, notify all your healthcare providers such as your primary care doctor, specialists, physical therapists, dentists etc.

Notify your oncologist if you have a heart history such as high blood pressure, heart attack, heart failure or stroke.

What is the most important information to know about Cabometyx?

If you develop a severe allergic reaction such as chest pain, shortness of breath or wheezing, call 911.

If you develop an allergic reaction such as rash, hives, itchiness and/ or fevers call your healthcare provider right away.

  • Serious bleeding complications can occur while taking Cabometyx. Please call your healthcare provider if you develop the following symptoms:
    • bloody stool
    • tarry stool
    • blood in urine
    • coughing up blood
    • throw up that looks like coffee grinds
    • bleeding gums
    • bleeding nose
    • abnormal bruising
    • feeling dizzy or lightheaded.
  • You may develop blood clots which can cause heart attacks or stroke. Call your healthcare provider right away if you experience any of these problems:
    • severe chest pain or pressure
    • pain in your arms, back, neck or jaw
    • shortness of breath
    • numbness or weakness on one side of your body
    • trouble talking
    • sudden severe headache
    • sudden vision changes
  • Cabometyx will cause high blood pressure which can cause strokes and heart failure.  Please check your blood pressure once a day, every day and notify your healthcare provider if your top number is greater than 150 and/or your bottom number is greater than 90.
  • You may develop diarrhea while taking Cabometyx which can lead to dehydration and electrolyte imbalance. Call your healthcare provider if you experience any of the following:
    • 3 or more loose watery stool in 24 hours
    • bloody stool
    • abdominal pain or cramping
    • fever of 100.4 F or greater
    • feeling dizzy or lightheaded
  • You may develop hand/foot syndrome which causes pain and swelling to the palms of your hand and/or soles of your feet. Notify your healthcare provider if you experience the following symptoms:
    • Rash
    • redness
    • pain
    • calluses or blisters
  • Severe kidney complications such as the build- up of protein in your urine. Please call your healthcare provider if you develop these symptoms:
    • swelling of the face, legs, arms, and/or abdomen
    • foamy or frothy urine
  • If you develop any wounds where your skin becomes open, notify your healthcare provider right away. Cabometyx will slow down wound healing and can lead to serious skin breakdown.
  • A severe condition called reversible posterior leukoencephalopathy syndrome (RPLS) can occur which causes swelling in your brain. Notify you healthcare provider immediately if you develop any of the following symptoms:
    • headaches
    • vision changes
    • confusion
    • seizures

What are other possible side effects of Cabometyx?

Common side effects include:

  • fatigue
  • vomiting
  • nausea
  • constipation
  • decreased appetite
  • rash/dry skin

Remember, these are not all the possible side effects of Cabometyx. Tell your healthcare provider if you have any side effects that bother you and are affecting your quality of life. Do not stop taking this medication until speaking to your healthcare provider for medical advice.  

For females, tell your doctor if you:

  • If you are pregnant or planning to become pregnant, taking Cabometyx during pregnancy may cause the death of an unborn baby or birth defects.
  • You should use effective birth control during your treatment with Cabometyx and for 4 months after you discontinue treatment.
  • Talk to your doctor about birth control methods to prevent pregnancy while you are talking Cabometyx 

What else should I tell my healthcare provider?

  • Bring a list to each visit of all your medications; including over the counter medications and supplements such as vitamins and herbal supplements. Cabometyx may affect how other medications work and other medications or supplements may have an effect on how Cabometyx works.

Patient Assistance Programs:

Exelixis® Access Services (EASE) is a support program that provides information about financial assistance for Cabometyx treatment.  Please call 1-844-900-EASE (3273) to find out more about the program.

Adapted from the Cabometyx (cabozantinib) package insert. Exelixis, Inc., revised 1/2020

KCA disclaimer statement:  You should rely primarily on your doctor for medical information.