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Cabometyx® (cabozantinib) for Advanced Kidney Cancer

Cabometyx is a medication used to treat advanced kidney cancer in adults

Dosage:  60mg once a day with a full glass of water; take at least 1 hour before or 2 hours after eating
How supplied: 20mg, 40mg and 60mg tablets  
Storage: Store at room temperature.   Do not take Cabometyx that is out of date.  As with all medications, keep out of the reach of children.
Schedule:  Cabometyx is taken by mouth daily at the same time every day. It should be taken on an empty stomach, i.e.at least one hour before meals or at least 2 hours after meals.  Do NOT take with food.

How should I take Cabometyx?

  • Take it exactly as your healthcare provider tells you
  • Do not take with food. Do not eat for at least 2 hours before and at least 1 hour after taking Cabometyx.
  • Swallow tablets whole with a full glass (8oz) of water.
  • Do not crush tablets
  • If you miss a dose, and your next dose is in:

Less than 12 hours, take your next dose at the normal time. Do not make up missed dose.

12 hours or more, take the missed dose as soon as you remember. Take your next dose at the normal time. 

What should I avoid while taking Cabometyx:

  • Do not drink grapefruit juice, eat grapefruit or take supplements containing grapefruit during your treatment with Cabometyx.  

What is the most important information to know about Cabometyx?

  • Cabometyx can cause severe or fatal side effects. Tell your oncology provider if you have any side effect that bothers you or that does not go away.
  • Your oncology provider may change your dose, temporarily stop, or permanently stop treatment if you have certain side effects.
  • It is important to read the FDA approved patient information packet that will come with your Cabometyx tablets

Before starting Cabometyx you should tell your healthcare provider about all of your medical conditions including if you:

  • have any unusual bleeding
  • have high blood pressure
  • have had surgery within the past 14 days or are planning to have surgery, including dental surgery or other dental procedures.  Cabometyx should be stopped 28 days before any scheduled surgery.
  • have liver problems
  • are pregnant or could become pregnant.  Cabometyx can harm your unborn baby. You should use an effective method of birth control while taking Cabometyx and for 4 months after your last dose of Cabometyx.  Your healthcare provider can counsel you on an appropriate method of birth control. If you become pregnant or think you are pregnant while taking Cabometyx, tell your healthcare provider right away.  
  • Are breastfeeding or plan to breastfeed.  It is not known if Cabometyx passes into the breast milk.  Do NOT breastfeed while taking Cabometyx or for 4 months after your last dose of Cabometyx.
  • Are allergic to any medications

What else should I tell my healthcare provider?

  • Bring a list to each visit of all your medications; including over the counter medications and supplements such as vitamins and herbal supplements. Cabometyx may affect how other medications work and other medications or supplements may have an effect on how Cabometyx works. 

What are the possible side effects of Cabometyx?

Serious side effects include:

  • Severe bleeding
  • Tear in your stomach or intestine (perforation)
  • Blood clots, stroke, heart attack, chest pain: seek treatment immediately if you get;
    • Swelling or pain in your arms or legs
    • Shortness of breath
    • Excessive sweating
    • Feel lightheaded or faint
    • Numbness or weakness especially on one side of your body
    • Sudden confusion or difficulty speaking
    • Sudden changes in your vision
    • Dizziness, loss of balance/coordination
    • Sudden and severe headache
  • Reversible Posterior Leukoencephalopathy Syndrome (RPLS) is a rare and reversible side effect.  Get emergency help immediately if you experience sudden severe headache, changes in vision, confusion or difficulty thinking. 
  • High blood pressure
  • Impaired wound healing
  • A skin condition called hand foot skin reaction causing sometimes severe pain on the palms of the hands and/or soles of the feet.
  • Diarrhea which can be severe. If needed,  your healthcare provider can prescribe medication to control the diarrhea.

Common side effects include:

  • fatigue
  • vomiting
  • nausea
  • constipation
  • decreased appetite
  • rash/dry skin

These are just some of the possible side effects of Cabometyx.  Please tell your healthcare provider if you have any side effects that bother you or that do not go away. 

For more information about Cabometyx ask your healthcare provider or pharmacist.

Patient Assistance Programs: 

Exelixis® Access Services (EASE) is a support program that provides information about financial assistance for Cabometyx treatment.  Please call 1-844-900-EASE (3273) to find out more about the program.

Adapted from the Cabometyx (cabozantinib) package insert. Exelixis, Inc. Dec 2017

KCA disclaimer statement:  You should rely primarily on your doctor for medical information.  www.kidneycancer.org