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A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

Introduction

  • Org Study ID: AREN1921
  • NTC ID: NCT04322318
  • Lead Sponsor Name: Children's Oncology Group
  • Status: RECRUITING

Conditions

  • Wilms Tumor

Brief Summary

This phase II trial studies how well combination chemotherapy works in treating patients with newly diagnosed stage II-IV diffuse anaplastic Wilms tumors (DAWT) or favorable histology Wilms tumors (FHWT) that have come back (relapsed). Drugs used in chemotherapy regimens such as UH-3 (vincristine, doxorubicin, cyclophosphamide, carboplatin, etoposide, and irinotecan) and ICE/Cyclo/Topo (ifosfamide, carboplatin, etoposide, cyclophosphamide, and topotecan) work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial may help doctors find out what effects, good and/or bad, regimen UH-3 has on patients with newly diagnosed DAWT and standard risk relapsed FHWT (those treated with only 2 drugs for the initial WT) and regimen ICE/Cyclo/Topo has on patients with high and very high risk relapsed FHWT (those treated with 3 or more drugs for the initial WT).

Eligibility Criteria

Inclusion Criteria:

* Patients with newly diagnosed stages 2 - 4 diffuse anaplastic Wilms tumor must be enrolled on AREN03B2 and have received an initial risk assignment showing DAWT (if anaplasia first identified at diagnostic, pre-treatment nephrectomy or biopsy) or a delayed nephrectomy classification showing DAWT (if anaplasia first noted at delayed nephrectomy) prior to enrollment on AREN1921. Prior enrollment on AREN03B2 is not an eligibility requirement for patients with relapsed favorable histology Wilms tumor.
* Patients must be =< 30 years old at study enrollment
* Patients with the following diagnoses are eligible for this study:

* Newly diagnosed stages 2 - 4 diffuse anaplastic Wilms tumor as confirmed by central review
* Favorable histology Wilms tumor at first relapse. Relapsed FHWT patients must have previously achieved remission for their initial FHWT diagnosis to be eligible for this study. The relapse risk groups are defined as follows, regardless of radiation therapy:

* Standard-Risk relapse: Patients who received two chemotherapy agents for frontline therapy; primarily actinomycin D and vincristine
* High-Risk relapse: Patients who received three chemotherapy agents for frontline therapy; primarily vincristine, actinomycin D and doxorubicin or vincristine, actinomycin D and irinotecan
* Very High-Risk relapse: Patients who received four or more chemotherapy agents as part of initial therapy; primarily regimen M or its variations
* Patients with newly diagnosed DAWT must have had histologic verification of the malignancy. For relapsed FHWT patients, biopsy to prove recurrence is encouraged, but not required

* Note: For relapsed FHWT patients, an institutional pathology report confirming favorable histology Wilms tumor (from relapse, if available, or from original diagnosis) must be available for upload prior to initiation of protocol therapy
* Patients with newly diagnosed Stages 2 - 4 diffuse anaplastic Wilms tumor must be enrolled on AREN1921 within 2 weeks of the tumor-directed surgery or biopsy procedure that first confirms a diagnosis of DAWT, whether at initial diagnostic procedure or delayed nephrectomy (such surgery/biopsy is day 0). For patients who received prior therapy for presumed favorable histology Wilms tumor, later confirmed to have diffuse anaplastic Wilms tumor at subsequent review of the initial biopsy
* Patients with newly diagnosed DAWT who undergo upfront nephrectomy must have at least 1 lymph node sampled prior to study enrollment
* Patients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1 or 2. Use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of age
* Patients must have a life expectancy of >= 8 weeks
* Diffuse Anaplastic Wilms Tumor: Patients with diffuse anaplastic histology must have had no prior systemic therapy, except in the following situations:

* Patients with diffuse anaplastic Wilms tumor who received no more than 12 weeks of pre nephrectomy chemotherapy for what was originally presumed to be favorable histology Wilms tumor, subsequently confirmed to be diffuse anaplastic Wilms tumor at delayed nephrectomy
* Patients with diffuse anaplastic Wilms tumor who received no more than 6 weeks of chemotherapy following upfront biopsy, initiated within 14 days of biopsy, for presumed favorable histology Wilms tumor based on institutional review, but subsequently corrected to diffuse anaplastic Wilms tumor based on the AREN03B2 initial risk assignment results (if available per current version of AREN03B2)
* Treatment consisting of vincristine/doxorubicin/cyclophosphamide initiated on an emergent basis and within allowed timing as described
* Note: Patients who received prior therapy for presumed favorable histology Wilms tumor, later identified to have diffuse anaplastic Wilms tumor as per above, must begin study treatment starting at cycle 3 (week 7) of regimen UH 3. Patients who received emergency radiation to preserve organ function are eligible as noted. Patients who received radiation as part of standard of care for presumed newly diagnosed favorable histology Wilms tumor, along with chemotherapy as noted above, prior to identification of diffuse anaplasia, are also eligible
* Relapsed Favorable Histology Wilms Tumor: Patients must not have received prior chemotherapy for their relapsed favorable histology Wilms tumor diagnosis. In addition, patients must have fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy prior to entering this study

* Myelosuppressive chemotherapy: Must not have received within 2 weeks of entry onto this study
* Radiation therapy (RT): >= 2 weeks (wks) must have elapsed for local palliative RT (small port); >= 6 months must have elapsed if prior craniospinal RT or if >= 50% radiation of pelvis; >= 6 wks must have elapsed if other substantial bone marrow (BM) radiation. Patients with relapsed favorable histology Wilms tumor who received emergency radiation to preserve organ function are eligible and do not need to washout with the above criteria
* Patients may not be receiving any other investigational agents (within 4 weeks prior to study enrollment)
* Peripheral absolute neutrophil count (ANC) >= 750/uL (performed within 7 days prior to enrollment)
* Platelet count >= 75,000/uL (transfusion independent) (performed within 7 days prior to enrollment)
* Hemoglobin >= 8.0 g/dL (may receive red blood cell [RBC] transfusions) (performed within 7 days prior to enrollment)
* Patients with high-risk or very high-risk relapsed FHWT who will be treated with regimen ICE/Cyclo/Topo, must have renal function assessed by creatinine clearance or radioisotope glomerular filtration rate (GFR) and meet the following requirement:

* Creatinine clearance or radioisotope GFR >= 60 mL/min/1.73 m^2 (performed within 7 days prior to enrollment)
* Patients diagnosed with stage 2-4 DAWT or standard risk relapsed FHWT, who will be treated with regimen UH 3, may either obtain a creatinine clearance, radioisotope GFR (meeting the above criteria of GFR >= 60 mL/min/1.73 m^2), or an adequate serum creatinine as per the following table:

* Age: Maximum Serum Creatinine (mg/dL)
* 1 month to < 6 months: 0.4 (male and female)
* 6 months to < 1 year: 0.5 (male and female)
* 1 to < 2 years: 0.6 (male and female)
* 2 to < 6 years: 0.8 (male and female)
* 6 to < 10 years: 1 (male and female)
* 10 to < 13 years: 1.2 (male and female)
* 13 to < 16 years: 1.5 (male), 1.4 (female)
* >= 16 years: 1.7 (male), 1.4 (female)
* Total bilirubin =< 1.5 x upper limit of normal (ULN) for age or direct bilirubin =< ULN for patients whose total bilirubin > 1.5 x ULN (performed within 7 days prior to enrollment)
* Serum glutamic-oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) or serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) < 2.5 x upper limit of normal (ULN) for age or =< 5 x ULN for patients with liver metastases (performed within 7 days prior to enrollment)
* Shortening fraction of >= 27% by echocardiogram, or ejection fraction of >= 50% by radionuclide angiogram (obtained within 21 days prior to enrollment and start of protocol therapy)

Exclusion Criteria:

* Patients with a history of bilateral Wilms tumor (synchronous or metachronous)
* Patients with any uncontrolled, intercurrent illness including, but not limited to, ongoing or active infection, or symptomatic congestive heart failure (defined as grade 2 or higher heart failure per Common Terminology Criteria for Adverse Events [CTCAE] version 5.0)
* Relapsed FHWT patients who did not receive frontline chemotherapy (e.g., very low risk FHWT initially observed without chemotherapy) or received only one chemotherapy agent for frontline therapy
* For patients with high-risk or very high-risk relapsed FHWT:

* Patients with renal tubular acidosis (RTA) as evidenced by serum bicarbonate < 16 mmol/L and serum phosphate =< 2 mg/dL (or < 0.8 mmol/L) without supplementation
* For stages 2-4 DAWT and standard-risk relapsed FHWT patients:

* Chronic inflammatory bowel disease and/or bowel obstruction
* Concomitant use of St. John's wort, which cannot be stopped prior to the start of trial treatment
* Female patients who are pregnant since fetal toxicities and teratogenic effects have been noted for several of the study drugs. A pregnancy test is required for female patients of childbearing potential
* Lactating females who plan to breastfeed their infants
* Sexually active patients of reproductive potential who have not agreed to use an effective contraceptive method for the duration of their study participation

Locations

Alabama
Facility Status Contact
Facility Children's Hospital of Alabama Birmingham, Alabama 35233 United States
Status RECRUITING
Contact Site Public Contact 205-638-9285 oncologyresearch@peds.uab.edu
Facility USA Health Strada Patient Care Center Mobile, Alabama 36604 United States
Status RECRUITING
Contact Site Public Contact 800-388-8721
Alaska
Facility Status Contact
Facility Providence Alaska Medical Center Anchorage, Alaska 99508 United States
Status RECRUITING
Arizona
Facility Status Contact
Facility Banner Children's at Desert Mesa, Arizona 85202 United States
Status RECRUITING
Contact Site Public Contact 480-412-3100
Facility Phoenix Childrens Hospital Phoenix, Arizona 85016 United States
Status RECRUITING
Contact Site Public Contact 602-546-0920
Facility Banner University Medical Center - Tucson Tucson, Arizona 85719 United States
Status RECRUITING
Contact Site Public Contact UACC-IIT@uacc.arizona.edu
Arkansas
Facility Status Contact
Facility Arkansas Children's Hospital Little Rock, Arkansas 72202-3591 United States
Status RECRUITING
Contact Site Public Contact 501-364-7373
California
Facility Status Contact
Facility Kaiser Permanente Downey Medical Center Downey, California 90242 United States
Status RECRUITING
Contact Site Public Contact 626-564-3455
Facility Loma Linda University Medical Center Loma Linda, California 92354 United States
Status RECRUITING
Contact Site Public Contact 909-558-4050
Facility Miller Children's and Women's Hospital Long Beach Long Beach, California 90806 United States
Status RECRUITING
Contact Site Public Contact 562-933-5600
Facility Children's Hospital Los Angeles Los Angeles, California 90027 United States
Status RECRUITING
Contact Site Public Contact 323-361-4110
Facility Cedars Sinai Medical Center Los Angeles, California 90048 United States
Status RECRUITING
Contact Site Public Contact 310-423-8965
Facility Mattel Children's Hospital UCLA Los Angeles, California 90095 United States
Status RECRUITING
Contact Site Public Contact 310-825-6708
Facility Valley Children's Hospital Madera, California 93636 United States
Status RECRUITING
Contact Site Public Contact 559-353-3000 Research@valleychildrens.org
Facility UCSF Benioff Children's Hospital Oakland Oakland, California 94609 United States
Status RECRUITING
Contact Site Public Contact 510-428-3264 cogbchoak@ucsf.edu
Facility Kaiser Permanente-Oakland Oakland, California 94611 United States
Status RECRUITING
Contact Site Public Contact 877-642-4691 Kpoct@kp.org
Facility Children's Hospital of Orange County Orange, California 92868 United States
Status RECRUITING
Contact Site Public Contact 714-509-8646 oncresearch@choc.org
Facility Lucile Packard Children's Hospital Stanford University Palo Alto, California 94304 United States
Status RECRUITING
Contact Site Public Contact 800-694-0012 ccto-office@stanford.edu
Facility University of California Davis Comprehensive Cancer Center Sacramento, California 95817 United States
Status RECRUITING
Contact Site Public Contact 916-734-3089
Facility Rady Children's Hospital - San Diego San Diego, California 92123 United States
Status RECRUITING
Contact Site Public Contact 858-966-5934
Facility UCSF Medical Center-Mission Bay San Francisco, California 94158 United States
Status RECRUITING
Contact Site Public Contact 877-827-3222 cancertrials@ucsf.edu
Colorado
Facility Status Contact
Facility Children's Hospital Colorado Aurora, Colorado 80045 United States
Status RECRUITING
Contact Site Public Contact 303-764-5056 josh.b.gordon@nsmtp.kp.org
Facility Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center Denver, Colorado 80218 United States
Status RECRUITING
Connecticut
Facility Status Contact
Facility Connecticut Children's Medical Center Hartford, Connecticut 06106 United States
Status RECRUITING
Contact Site Public Contact 860-545-9981
Facility Yale University New Haven, Connecticut 06520 United States
Status RECRUITING
Contact Site Public Contact 203-785-5702 canceranswers@yale.edu
Delaware
Facility Status Contact
Facility Alfred I duPont Hospital for Children Wilmington, Delaware 19803 United States
Status RECRUITING
Contact Site Public Contact 302-651-5572 Allison.bruce@nemours.org
District of Columbia
Facility Status Contact
Facility MedStar Georgetown University Hospital Washington, District of Columbia 20007 United States
Status RECRUITING
Contact Site Public Contact 202-444-2223
Facility Children's National Medical Center Washington, District of Columbia 20010 United States
Status RECRUITING
Florida
Facility Status Contact
Facility Golisano Children's Hospital of Southwest Florida Fort Myers, Florida 33908 United States
Status RECRUITING
Contact Site Public Contact 239-343-5333 molly.arnstrom@leehealth.org
Facility University of Florida Health Science Center - Gainesville Gainesville, Florida 32610 United States
Status RECRUITING
Contact Site Public Contact 352-273-8010 cancer-center@ufl.edu
Facility Memorial Regional Hospital/Joe DiMaggio Children's Hospital Hollywood, Florida 33021 United States
Status RECRUITING
Contact Site Public Contact 954-265-1847 OHR@mhs.net
Facility Nemours Children's Clinic-Jacksonville Jacksonville, Florida 32207 United States
Status RECRUITING
Contact Site Public Contact 302-651-5572 Allison.bruce@nemours.org
Facility University of Miami Miller School of Medicine-Sylvester Cancer Center Miami, Florida 33136 United States
Status ACTIVE_NOT_RECRUITING
Contact N/A
Facility Nicklaus Children's Hospital Miami, Florida 33155 United States
Status RECRUITING
Contact Site Public Contact 888-624-2778
Facility Arnold Palmer Hospital for Children Orlando, Florida 32806 United States
Status RECRUITING
Facility Nemours Children's Hospital Orlando, Florida 32827 United States
Status RECRUITING
Contact Site Public Contact 302-651-5572 Allison.bruce@nemours.org
Facility Sacred Heart Hospital Pensacola, Florida 32504 United States
Status RECRUITING
Contact Site Public Contact 850-416-4611 eebrou@ascension.org
Facility Johns Hopkins All Children's Hospital Saint Petersburg, Florida 33701 United States
Status RECRUITING
Contact Site Public Contact 727-767-4784 Ashley.Repp@jhmi.edu
Facility Tampa General Hospital Tampa, Florida 33606 United States
Status RECRUITING
Contact Site Public Contact 813-844-7829 syapchanyk@tgh.org
Facility Saint Joseph's Hospital/Children's Hospital-Tampa Tampa, Florida 33607 United States
Status RECRUITING
Contact Site Public Contact 813-357-0849 jennifer.manns@baycare.org
Facility Saint Mary's Medical Center West Palm Beach, Florida 33407 United States
Status RECRUITING
Contact Site Public Contact 561-822-4745
Georgia
Facility Status Contact
Facility Children's Healthcare of Atlanta - Arthur M Blank Hospital Atlanta, Georgia 30329 United States
Status RECRUITING
Contact Site Public Contact 404-785-2025 Leann.Schilling@choa.org
Facility Atrium Health Navicent Macon, Georgia 31201 United States
Status RECRUITING
Contact Site Public Contact 478-633-2152 andrew.weatherall@atriumhealth.org
Facility Memorial Health University Medical Center Savannah, Georgia 31404 United States
Status RECRUITING
Contact Site Public Contact 912-350-7887 Lorraine.OHara@hcahealthcare.com
Hawaii
Facility Status Contact
Facility Kapiolani Medical Center for Women and Children Honolulu, Hawaii 96826 United States
Status RECRUITING
Contact Site Public Contact 808-983-6090
Idaho
Facility Status Contact
Facility Saint Luke's Cancer Institute - Boise Boise, Idaho 83712 United States
Status RECRUITING
Contact Site Public Contact 208-381-2774 eslinget@slhs.org
Illinois
Facility Status Contact
Facility Lurie Children's Hospital-Chicago Chicago, Illinois 60611 United States
Status RECRUITING
Contact Site Public Contact 773-880-4562
Facility University of Illinois Chicago, Illinois 60612 United States
Status RECRUITING
Contact Site Public Contact 312-355-3046
Facility University of Chicago Comprehensive Cancer Center Chicago, Illinois 60637 United States
Status RECRUITING
Facility Loyola University Medical Center Maywood, Illinois 60153 United States
Status RECRUITING
Contact Site Public Contact 708-226-4357
Facility Advocate Children's Hospital-Oak Lawn Oak Lawn, Illinois 60453 United States
Status RECRUITING
Contact Site Public Contact 847-723-7570
Facility Advocate Children's Hospital-Park Ridge Park Ridge, Illinois 60068 United States
Status RECRUITING
Contact Site Public Contact helpdesk@childrensoncologygroup.org
Facility Saint Jude Midwest Affiliate Peoria, Illinois 61637 United States
Status RECRUITING
Contact Site Public Contact 888-226-4343
Facility Southern Illinois University School of Medicine Springfield, Illinois 62702 United States
Status RECRUITING
Contact Site Public Contact 217-545-7929
Indiana
Facility Status Contact
Facility Riley Hospital for Children Indianapolis, Indiana 46202 United States
Status RECRUITING
Contact Site Public Contact 800-248-1199
Facility Ascension Saint Vincent Indianapolis Hospital Indianapolis, Indiana 46260 United States
Status RECRUITING
Contact Site Public Contact 317-338-2194 research@stvincent.org
Iowa
Facility Status Contact
Facility Blank Children's Hospital Des Moines, Iowa 50309 United States
Status RECRUITING
Contact Site Public Contact 515-241-8912 samantha.mallory@unitypoint.org
Facility University of Iowa/Holden Comprehensive Cancer Center Iowa City, Iowa 52242 United States
Status RECRUITING
Contact Site Public Contact 800-237-1225
Kentucky
Facility Status Contact
Facility University of Kentucky/Markey Cancer Center Lexington, Kentucky 40536 United States
Status RECRUITING
Contact Site Public Contact 859-257-3379
Facility Norton Children's Hospital Louisville, Kentucky 40202 United States
Status RECRUITING
Louisiana
Facility Status Contact
Facility Children's Hospital New Orleans New Orleans, Louisiana 70118 United States
Status RECRUITING
Contact Site Public Contact CHResearch@lcmchealth.org
Facility Ochsner Medical Center Jefferson New Orleans, Louisiana 70121 United States
Status RECRUITING
Contact Site Public Contact 504-842-8084 Elisemarie.curry@ochsner.org
Maine
Facility Status Contact
Facility Eastern Maine Medical Center Bangor, Maine 04401 United States
Status RECRUITING
Contact Site Public Contact 207-973-4274
Facility Maine Children's Cancer Program Scarborough, Maine 04074 United States
Status RECRUITING
Contact Site Public Contact 207-396-7581 sverwys@mmc.org
Maryland
Facility Status Contact
Facility Sinai Hospital of Baltimore Baltimore, Maryland 21215 United States
Status RECRUITING
Contact Site Public Contact 410-601-6120 pridgely@lifebridgehealth.org
Facility Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland 21287 United States
Status RECRUITING
Contact Site Public Contact 410-955-8804 jhcccro@jhmi.edu
Massachusetts
Facility Status Contact
Facility Tufts Children's Hospital Boston, Massachusetts 02111 United States
Status ACTIVE_NOT_RECRUITING
Contact N/A
Facility Dana-Farber Cancer Institute Boston, Massachusetts 02215 United States
Status RECRUITING
Contact Site Public Contact 877-442-3324
Facility UMass Memorial Medical Center - University Campus Worcester, Massachusetts 01655 United States
Status RECRUITING
Contact Site Public Contact 508-856-3216 cancer.research@umassmed.edu
Michigan
Facility Status Contact
Facility C S Mott Children's Hospital Ann Arbor, Michigan 48109 United States
Status RECRUITING
Contact Site Public Contact 800-865-1125
Facility Children's Hospital of Michigan Detroit, Michigan 48201 United States
Status RECRUITING
Contact Site Public Contact helpdesk@childrensoncologygroup.org
Facility Michigan State University Clinical Center East Lansing, Michigan 48824 United States
Status RECRUITING
Contact Site Public Contact 517-975-9547
Facility Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital Grand Rapids, Michigan 49503 United States
Status RECRUITING
Contact Site Public Contact 616-267-1925 crcwm-regulatory@crcwm.org
Facility Bronson Methodist Hospital Kalamazoo, Michigan 49007 United States
Status RECRUITING
Contact Site Public Contact 616-391-1230 crcwm-regulatory@crcwm.org
Facility Corewell Health Children's Royal Oak, Michigan 48073 United States
Status RECRUITING
Contact Site Public Contact 248-551-7695
Minnesota
Facility Status Contact
Facility Children's Hospitals and Clinics of Minnesota - Minneapolis Minneapolis, Minnesota 55404 United States
Status RECRUITING
Contact Site Public Contact 612-813-5913 pauline.mitby@childrensmn.org
Facility University of Minnesota/Masonic Cancer Center Minneapolis, Minnesota 55455 United States
Status RECRUITING
Contact Site Public Contact 612-624-2620
Facility Mayo Clinic in Rochester Rochester, Minnesota 55905 United States
Status RECRUITING
Contact Site Public Contact 855-776-0015
Mississippi
Facility Status Contact
Facility University of Mississippi Medical Center Jackson, Mississippi 39216 United States
Status RECRUITING
Contact Site Public Contact 601-815-6700
Missouri
Facility Status Contact
Facility University of Missouri Children's Hospital Columbia, Missouri 65212 United States
Status RECRUITING
Contact Site Public Contact 573-882-1960 snwq62@health.missouri.edu
Facility Children's Mercy Hospitals and Clinics Kansas City, Missouri 64108 United States
Status RECRUITING
Contact Site Public Contact 816-302-6808 rryan@cmh.edu
Facility Cardinal Glennon Children's Medical Center Saint Louis, Missouri 63104 United States
Status RECRUITING
Contact Site Public Contact 314-268-4000
Facility Washington University School of Medicine Saint Louis, Missouri 63110 United States
Status RECRUITING
Contact Site Public Contact 800-600-3606 info@siteman.wustl.edu
Facility Mercy Hospital Saint Louis Saint Louis, Missouri 63141 United States
Status RECRUITING
Contact Site Public Contact 314-251-7066
Nebraska
Facility Status Contact
Facility Children's Hospital and Medical Center of Omaha Omaha, Nebraska 68114 United States
Status RECRUITING
Contact Site Public Contact 402-955-3949
Facility University of Nebraska Medical Center Omaha, Nebraska 68198 United States
Status RECRUITING
Contact Site Public Contact 402-559-6941 unmcrsa@unmc.edu
Nevada
Facility Status Contact
Facility University Medical Center of Southern Nevada Las Vegas, Nevada 89102 United States
Status RECRUITING
Contact Site Public Contact 702-384-0013 research@sncrf.org
Facility Sunrise Hospital and Medical Center Las Vegas, Nevada 89109 United States
Status RECRUITING
Contact Site Public Contact 702-384-0013 research@sncrf.org
Facility Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas, Nevada 89135 United States
Status RECRUITING
Contact Site Public Contact 702-384-0013 research@sncrf.org
Facility Summerlin Hospital Medical Center Las Vegas, Nevada 89144 United States
Status RECRUITING
Contact Site Public Contact 702-384-0013 research@sncrf.org
Facility Renown Regional Medical Center Reno, Nevada 89502 United States
Status RECRUITING
Contact Site Public Contact 702-384-0013 research@sncrf.org
New Hampshire
Facility Status Contact
Facility Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon, New Hampshire 03756 United States
Status RECRUITING
New Jersey
Facility Status Contact
Facility Hackensack University Medical Center Hackensack, New Jersey 07601 United States
Status RECRUITING
Contact Site Public Contact 551-996-2897
Facility Morristown Medical Center Morristown, New Jersey 07960 United States
Status RECRUITING
Contact Site Public Contact 973-971-5900
Facility Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital New Brunswick, New Jersey 08903 United States
Status RECRUITING
Contact Site Public Contact 732-235-8675
Facility Saint Joseph's Regional Medical Center Paterson, New Jersey 07503 United States
Status RECRUITING
Contact Site Public Contact 973-754-2207 HallL@sjhmc.org
New York
Facility Status Contact
Facility Albany Medical Center Albany, New York 12208 United States
Status RECRUITING
Contact Site Public Contact 518-262-5513
Facility Montefiore Medical Center - Moses Campus Bronx, New York 10467 United States
Status RECRUITING
Contact Site Public Contact 718-379-6866 eskwak@montefiore.org
Facility Roswell Park Cancer Institute Buffalo, New York 14263 United States
Status RECRUITING
Contact Site Public Contact 800-767-9355 askroswell@roswellpark.org
Facility The Steven and Alexandra Cohen Children's Medical Center of New York New Hyde Park, New York 11040 United States
Status RECRUITING
Contact Site Public Contact 718-470-3460
Facility NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center New York, New York 10032 United States
Status RECRUITING
Facility Memorial Sloan Kettering Cancer Center New York, New York 10065 United States
Status RECRUITING
Contact Site Public Contact 212-639-7592
Facility NYP/Weill Cornell Medical Center New York, New York 10065 United States
Status RECRUITING
Contact Site Public Contact 212-746-1848
Facility University of Rochester Rochester, New York 14642 United States
Status RECRUITING
Contact Site Public Contact 585-275-5830
Facility Stony Brook University Medical Center Stony Brook, New York 11794 United States
Status RECRUITING
Contact Site Public Contact 800-862-2215
Facility State University of New York Upstate Medical University Syracuse, New York 13210 United States
Status RECRUITING
Contact Site Public Contact 315-464-5476
Facility New York Medical College Valhalla, New York 10595 United States
Status RECRUITING
Contact Site Public Contact 914-594-3794
North Carolina
Facility Status Contact
Facility Mission Hospital Asheville, North Carolina 28801 United States
Status RECRUITING
Facility Carolinas Medical Center/Levine Cancer Institute Charlotte, North Carolina 28203 United States
Status RECRUITING
Contact Site Public Contact 800-804-9376
Facility Novant Health Presbyterian Medical Center Charlotte, North Carolina 28204 United States
Status RECRUITING
Contact Site Public Contact 980-201-6360 kashah@novanthealth.org
Facility Duke University Medical Center Durham, North Carolina 27710 United States
Status RECRUITING
Contact Site Public Contact 888-275-3853
Facility East Carolina University Greenville, North Carolina 27834 United States
Status RECRUITING
Contact Site Public Contact 252-744-1015 eubankss@ecu.edu
Facility Wake Forest University Health Sciences Winston-Salem, North Carolina 27157 United States
Status RECRUITING
Contact Site Public Contact 336-713-6771
North Dakota
Facility Status Contact
Facility Sanford Broadway Medical Center Fargo, North Dakota 58122 United States
Status RECRUITING
Ohio
Facility Status Contact
Facility Children's Hospital Medical Center of Akron Akron, Ohio 44308 United States
Status RECRUITING
Contact Site Public Contact 330-543-3193
Facility Cincinnati Children's Hospital Medical Center Cincinnati, Ohio 45229 United States
Status RECRUITING
Contact Site Public Contact 513-636-2799 cancer@cchmc.org
Facility Rainbow Babies and Childrens Hospital Cleveland, Ohio 44106 United States
Status RECRUITING
Contact Site Public Contact 216-844-5437
Facility Cleveland Clinic Foundation Cleveland, Ohio 44195 United States
Status RECRUITING
Contact Site Public Contact 866-223-8100 TaussigResearch@ccf.org
Facility Nationwide Children's Hospital Columbus, Ohio 43205 United States
Status RECRUITING
Facility Dayton Children's Hospital Dayton, Ohio 45404 United States
Status RECRUITING
Contact Site Public Contact 800-228-4055
Facility ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital Toledo, Ohio 43606 United States
Status RECRUITING
Contact Site Public Contact 419-824-1842 PCIOncResearch@promedica.org
Oklahoma
Facility Status Contact
Facility University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma 73104 United States
Status RECRUITING
Contact Site Public Contact 405-271-8777 ou-clinical-trials@ouhsc.edu
Oregon
Facility Status Contact
Facility Legacy Emanuel Children's Hospital Portland, Oregon 97227 United States
Status RECRUITING
Contact Site Public Contact 503-413-2560
Facility Oregon Health and Science University Portland, Oregon 97239 United States
Status RECRUITING
Contact Site Public Contact 503-494-1080 trials@ohsu.edu
Pennsylvania
Facility Status Contact
Facility Lehigh Valley Hospital-Cedar Crest Allentown, Pennsylvania 18103 United States
Status RECRUITING
Contact Site Public Contact 610-402-9543 Morgan_M.Horton@lvhn.org
Facility Geisinger Medical Center Danville, Pennsylvania 17822 United States
Status RECRUITING
Contact Site Public Contact 570-271-5251 HemonCCTrials@geisinger.edu
Facility Penn State Children's Hospital Hershey, Pennsylvania 17033 United States
Status RECRUITING
Contact Site Public Contact 717-531-6012
Facility Children's Hospital of Philadelphia Philadelphia, Pennsylvania 19104 United States
Status RECRUITING
Contact Site Public Contact 267-425-5544 CancerTrials@email.chop.edu
Facility Saint Christopher's Hospital for Children Philadelphia, Pennsylvania 19134 United States
Status RECRUITING
Contact Site Public Contact 215-427-8991
Facility Children's Hospital of Pittsburgh of UPMC Pittsburgh, Pennsylvania 15224 United States
Status RECRUITING
Contact Site Public Contact 412-692-8570 jean.tersak@chp.edu
Rhode Island
Facility Status Contact
Facility Rhode Island Hospital Providence, Rhode Island 02903 United States
Status RECRUITING
Contact Site Public Contact 401-444-1488
South Carolina
Facility Status Contact
Facility Medical University of South Carolina Charleston, South Carolina 29425 United States
Status SUSPENDED
Contact N/A
Facility Prisma Health Richland Hospital Columbia, South Carolina 29203 United States
Status RECRUITING
Contact Site Public Contact 864-241-6251
Facility BI-LO Charities Children's Cancer Center Greenville, South Carolina 29605 United States
Status RECRUITING
Contact Site Public Contact 864-241-6251
South Dakota
Facility Status Contact
Facility Sanford USD Medical Center - Sioux Falls Sioux Falls, South Dakota 57117-5134 United States
Status RECRUITING
Tennessee
Facility Status Contact
Facility T C Thompson Children's Hospital Chattanooga, Tennessee 37403 United States
Status ACTIVE_NOT_RECRUITING
Contact N/A
Facility East Tennessee Childrens Hospital Knoxville, Tennessee 37916 United States
Status RECRUITING
Contact Site Public Contact 865-541-8266
Facility Saint Jude Children's Research Hospital Memphis, Tennessee 38105 United States
Status RECRUITING
Contact Site Public Contact 888-226-4343 referralinfo@stjude.org
Facility The Children's Hospital at TriStar Centennial Nashville, Tennessee 37203 United States
Status RECRUITING
Contact Site Public Contact 615-342-1919
Facility Vanderbilt University/Ingram Cancer Center Nashville, Tennessee 37232 United States
Status RECRUITING
Contact Site Public Contact 800-811-8480
Texas
Facility Status Contact
Facility Texas Tech University Health Sciences Center-Amarillo Amarillo, Texas 79106 United States
Status RECRUITING
Contact Site Public Contact 806-354-5411
Facility Dell Children's Medical Center of Central Texas Austin, Texas 78723 United States
Status RECRUITING
Facility Driscoll Children's Hospital Corpus Christi, Texas 78411 United States
Status RECRUITING
Contact Site Public Contact 361-694-5311 Crystal.DeLosSantos@dchstx.org
Facility Medical City Dallas Hospital Dallas, Texas 75230 United States
Status RECRUITING
Contact Site Public Contact 972-566-5588
Facility UT Southwestern/Simmons Cancer Center-Dallas Dallas, Texas 75390 United States
Status RECRUITING
Facility El Paso Children's Hospital El Paso, Texas 79905 United States
Status RECRUITING
Contact Site Public Contact 915-298-5444 ranjan.bista@ttuhsc.edu
Facility Cook Children's Medical Center Fort Worth, Texas 76104 United States
Status RECRUITING
Facility Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Houston, Texas 77030 United States
Status RECRUITING
Contact Site Public Contact 713-798-1354 burton@bcm.edu
Facility M D Anderson Cancer Center Houston, Texas 77030 United States
Status SUSPENDED
Contact N/A
Facility Covenant Children's Hospital Lubbock, Texas 79410 United States
Status RECRUITING
Contact Site Public Contact 806-725-8657 mbisbee@providence.org
Facility UMC Cancer Center / UMC Health System Lubbock, Texas 79415 United States
Status RECRUITING
Contact Site Public Contact 806-775-8590
Facility Children's Hospital of San Antonio San Antonio, Texas 78207 United States
Status RECRUITING
Contact Site Public Contact 210-704-2894 bridget.medina@christushealth.org
Facility Methodist Children's Hospital of South Texas San Antonio, Texas 78229 United States
Status RECRUITING
Facility University of Texas Health Science Center at San Antonio San Antonio, Texas 78229 United States
Status RECRUITING
Contact Site Public Contact 210-450-3800 phoresearchoffice@uthscsa.edu
Utah
Facility Status Contact
Facility Primary Children's Hospital Salt Lake City, Utah 84113 United States
Status RECRUITING
Contact Site Public Contact 801-585-5270
Virginia
Facility Status Contact
Facility University of Virginia Cancer Center Charlottesville, Virginia 22908 United States
Status RECRUITING
Facility Inova Fairfax Hospital Falls Church, Virginia 22042 United States
Status RECRUITING
Contact Site Public Contact 703-208-6650 Stephanie.VanBebber@inova.org
Facility Children's Hospital of The King's Daughters Norfolk, Virginia 23507 United States
Status RECRUITING
Contact Site Public Contact 757-668-7243 CCBDCresearch@chkd.org
Facility Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia 23298 United States
Status RECRUITING
Contact Site Public Contact CTOclinops@vcu.edu
Facility Carilion Children's Roanoke, Virginia 24014 United States
Status RECRUITING
Contact Site Public Contact 540-266-6238 wpmccarty@carilionclinic.org
Washington
Facility Status Contact
Facility Seattle Children's Hospital Seattle, Washington 98105 United States
Status RECRUITING
Contact Site Public Contact 866-987-2000
Facility Providence Sacred Heart Medical Center and Children's Hospital Spokane, Washington 99204 United States
Status RECRUITING
Contact Site Public Contact 800-228-6618 HopeBeginsHere@providence.org
Facility Mary Bridge Children's Hospital and Health Center Tacoma, Washington 98405 United States
Status RECRUITING
Contact Site Public Contact 253-403-1461 research@multicare.org
Facility Madigan Army Medical Center Tacoma, Washington 98431 United States
Status RECRUITING
Contact Site Public Contact 253-968-6144 melissa.a.forouhar.mil@health.mil
West Virginia
Facility Status Contact
Facility West Virginia University Charleston Division Charleston, West Virginia 25304 United States
Status RECRUITING
Contact Site Public Contact 304-388-9944
Facility Edwards Comprehensive Cancer Center Huntington, West Virginia 25701 United States
Status RECRUITING
Contact Site Public Contact 304-399-6566 Christina.Cole@chhi.org
Wisconsin
Facility Status Contact
Facility University of Wisconsin Carbone Cancer Center - University Hospital Madison, Wisconsin 53792 United States
Status RECRUITING
Contact Site Public Contact 800-622-8922 clinicaltrials@cancer.wisc.edu
Facility Marshfield Medical Center-Marshfield Marshfield, Wisconsin 54449 United States
Status SUSPENDED
Contact N/A
Facility Children's Hospital of Wisconsin Milwaukee, Wisconsin 53226 United States
Status RECRUITING
Contact Site Public Contact 414-955-4727 MACCCTO@mcw.edu