A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT
Introduction
- Org Study ID: AREN1921
- NTC ID: NCT04322318
- Lead Sponsor Name: Children's Oncology Group
- Status: RECRUITING
Conditions
- Wilms Tumor
Brief Summary
This phase II trial studies how well combination chemotherapy works in treating patients with newly diagnosed stage II-IV diffuse anaplastic Wilms tumors (DAWT) or favorable histology Wilms tumors (FHWT) that have come back (relapsed). Drugs used in chemotherapy regimens such as UH-3 (vincristine, doxorubicin, cyclophosphamide, carboplatin, etoposide, and irinotecan) and ICE/Cyclo/Topo (ifosfamide, carboplatin, etoposide, cyclophosphamide, and topotecan) work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial may help doctors find out what effects, good and/or bad, regimen UH-3 has on patients with newly diagnosed DAWT and standard risk relapsed FHWT (those treated with only 2 drugs for the initial WT) and regimen ICE/Cyclo/Topo has on patients with high and very high risk relapsed FHWT (those treated with 3 or more drugs for the initial WT).
Eligibility Criteria
Inclusion Criteria:
* Patients with newly diagnosed stages 2 - 4 diffuse anaplastic Wilms tumor must be enrolled on AREN03B2 and have received an initial risk assignment showing DAWT (if anaplasia first identified at diagnostic, pre-treatment nephrectomy or biopsy) or a delayed nephrectomy classification showing DAWT (if anaplasia first noted at delayed nephrectomy) prior to enrollment on AREN1921. Prior enrollment on AREN03B2 is not an eligibility requirement for patients with relapsed favorable histology Wilms tumor.
* Patients must be =< 30 years old at study enrollment
* Patients with the following diagnoses are eligible for this study:
* Newly diagnosed stages 2 - 4 diffuse anaplastic Wilms tumor as confirmed by central review
* Favorable histology Wilms tumor at first relapse. Relapsed FHWT patients must have previously achieved remission for their initial FHWT diagnosis to be eligible for this study. The relapse risk groups are defined as follows, regardless of radiation therapy:
* Standard-Risk relapse: Patients who received two chemotherapy agents for frontline therapy; primarily actinomycin D and vincristine
* High-Risk relapse: Patients who received three chemotherapy agents for frontline therapy; primarily vincristine, actinomycin D and doxorubicin or vincristine, actinomycin D and irinotecan
* Very High-Risk relapse: Patients who received four or more chemotherapy agents as part of initial therapy; primarily regimen M or its variations
* Patients with newly diagnosed DAWT must have had histologic verification of the malignancy. For relapsed FHWT patients, biopsy to prove recurrence is encouraged, but not required
* Note: For relapsed FHWT patients, an institutional pathology report confirming favorable histology Wilms tumor (from relapse, if available, or from original diagnosis) must be available for upload prior to initiation of protocol therapy
* Patients with newly diagnosed Stages 2 - 4 diffuse anaplastic Wilms tumor must be enrolled on AREN1921 within 2 weeks of the tumor-directed surgery or biopsy procedure that first confirms a diagnosis of DAWT, whether at initial diagnostic procedure or delayed nephrectomy (such surgery/biopsy is day 0). For patients who received prior therapy for presumed favorable histology Wilms tumor, later confirmed to have diffuse anaplastic Wilms tumor at subsequent review of the initial biopsy
* Patients with newly diagnosed DAWT who undergo upfront nephrectomy must have at least 1 lymph node sampled prior to study enrollment
* Patients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1 or 2. Use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of age
* Patients must have a life expectancy of >= 8 weeks
* Diffuse Anaplastic Wilms Tumor: Patients with diffuse anaplastic histology must have had no prior systemic therapy, except in the following situations:
* Patients with diffuse anaplastic Wilms tumor who received no more than 12 weeks of pre nephrectomy chemotherapy for what was originally presumed to be favorable histology Wilms tumor, subsequently confirmed to be diffuse anaplastic Wilms tumor at delayed nephrectomy
* Patients with diffuse anaplastic Wilms tumor who received no more than 6 weeks of chemotherapy following upfront biopsy, initiated within 14 days of biopsy, for presumed favorable histology Wilms tumor based on institutional review, but subsequently corrected to diffuse anaplastic Wilms tumor based on the AREN03B2 initial risk assignment results (if available per current version of AREN03B2)
* Treatment consisting of vincristine/doxorubicin/cyclophosphamide initiated on an emergent basis and within allowed timing as described
* Note: Patients who received prior therapy for presumed favorable histology Wilms tumor, later identified to have diffuse anaplastic Wilms tumor as per above, must begin study treatment starting at cycle 3 (week 7) of regimen UH 3. Patients who received emergency radiation to preserve organ function are eligible as noted. Patients who received radiation as part of standard of care for presumed newly diagnosed favorable histology Wilms tumor, along with chemotherapy as noted above, prior to identification of diffuse anaplasia, are also eligible
* Relapsed Favorable Histology Wilms Tumor: Patients must not have received prior chemotherapy for their relapsed favorable histology Wilms tumor diagnosis. In addition, patients must have fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy prior to entering this study
* Myelosuppressive chemotherapy: Must not have received within 2 weeks of entry onto this study
* Radiation therapy (RT): >= 2 weeks (wks) must have elapsed for local palliative RT (small port); >= 6 months must have elapsed if prior craniospinal RT or if >= 50% radiation of pelvis; >= 6 wks must have elapsed if other substantial bone marrow (BM) radiation. Patients with relapsed favorable histology Wilms tumor who received emergency radiation to preserve organ function are eligible and do not need to washout with the above criteria
* Patients may not be receiving any other investigational agents (within 4 weeks prior to study enrollment)
* Peripheral absolute neutrophil count (ANC) >= 750/uL (performed within 7 days prior to enrollment)
* Platelet count >= 75,000/uL (transfusion independent) (performed within 7 days prior to enrollment)
* Hemoglobin >= 8.0 g/dL (may receive red blood cell [RBC] transfusions) (performed within 7 days prior to enrollment)
* Patients with high-risk or very high-risk relapsed FHWT who will be treated with regimen ICE/Cyclo/Topo, must have renal function assessed by creatinine clearance or radioisotope glomerular filtration rate (GFR) and meet the following requirement:
* Creatinine clearance or radioisotope GFR >= 60 mL/min/1.73 m^2 (performed within 7 days prior to enrollment)
* Patients diagnosed with stage 2-4 DAWT or standard risk relapsed FHWT, who will be treated with regimen UH 3, may either obtain a creatinine clearance, radioisotope GFR (meeting the above criteria of GFR >= 60 mL/min/1.73 m^2), or an adequate serum creatinine as per the following table:
* Age: Maximum Serum Creatinine (mg/dL)
* 1 month to < 6 months: 0.4 (male and female)
* 6 months to < 1 year: 0.5 (male and female)
* 1 to < 2 years: 0.6 (male and female)
* 2 to < 6 years: 0.8 (male and female)
* 6 to < 10 years: 1 (male and female)
* 10 to < 13 years: 1.2 (male and female)
* 13 to < 16 years: 1.5 (male), 1.4 (female)
* >= 16 years: 1.7 (male), 1.4 (female)
* Total bilirubin =< 1.5 x upper limit of normal (ULN) for age or direct bilirubin =< ULN for patients whose total bilirubin > 1.5 x ULN (performed within 7 days prior to enrollment)
* Serum glutamic-oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) or serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) < 2.5 x upper limit of normal (ULN) for age or =< 5 x ULN for patients with liver metastases (performed within 7 days prior to enrollment)
* Shortening fraction of >= 27% by echocardiogram, or ejection fraction of >= 50% by radionuclide angiogram (obtained within 21 days prior to enrollment and start of protocol therapy)
Exclusion Criteria:
* Patients with a history of bilateral Wilms tumor (synchronous or metachronous)
* Patients with any uncontrolled, intercurrent illness including, but not limited to, ongoing or active infection, or symptomatic congestive heart failure (defined as grade 2 or higher heart failure per Common Terminology Criteria for Adverse Events [CTCAE] version 5.0)
* Relapsed FHWT patients who did not receive frontline chemotherapy (e.g., very low risk FHWT initially observed without chemotherapy) or received only one chemotherapy agent for frontline therapy
* For patients with high-risk or very high-risk relapsed FHWT:
* Patients with renal tubular acidosis (RTA) as evidenced by serum bicarbonate < 16 mmol/L and serum phosphate =< 2 mg/dL (or < 0.8 mmol/L) without supplementation
* For stages 2-4 DAWT and standard-risk relapsed FHWT patients:
* Chronic inflammatory bowel disease and/or bowel obstruction
* Concomitant use of St. John's wort, which cannot be stopped prior to the start of trial treatment
* Female patients who are pregnant since fetal toxicities and teratogenic effects have been noted for several of the study drugs. A pregnancy test is required for female patients of childbearing potential
* Lactating females who plan to breastfeed their infants
* Sexually active patients of reproductive potential who have not agreed to use an effective contraceptive method for the duration of their study participation
Locations
Facility | Status | Contact |
---|---|---|
Facility
Children's Hospital of Alabama
Birmingham,
Alabama 35233
United States
Status
RECRUITING
|
RECRUITING | |
Facility
USA Health Strada Patient Care Center
Mobile,
Alabama 36604
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Providence Alaska Medical Center
Anchorage,
Alaska 99508
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Banner Children's at Desert
Mesa,
Arizona 85202
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Phoenix Childrens Hospital
Phoenix,
Arizona 85016
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Banner University Medical Center - Tucson
Tucson,
Arizona 85719
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Arkansas Children's Hospital
Little Rock,
Arkansas 72202-3591
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Kaiser Permanente Downey Medical Center
Downey,
California 90242
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Loma Linda University Medical Center
Loma Linda,
California 92354
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Miller Children's and Women's Hospital Long Beach
Long Beach,
California 90806
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Children's Hospital Los Angeles
Los Angeles,
California 90027
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Cedars Sinai Medical Center
Los Angeles,
California 90048
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Mattel Children's Hospital UCLA
Los Angeles,
California 90095
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Valley Children's Hospital
Madera,
California 93636
United States
Status
RECRUITING
|
RECRUITING | |
Facility
UCSF Benioff Children's Hospital Oakland
Oakland,
California 94609
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Kaiser Permanente-Oakland
Oakland,
California 94611
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Children's Hospital of Orange County
Orange,
California 92868
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Lucile Packard Children's Hospital Stanford University
Palo Alto,
California 94304
United States
Status
RECRUITING
|
RECRUITING | |
Facility
University of California Davis Comprehensive Cancer Center
Sacramento,
California 95817
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Rady Children's Hospital - San Diego
San Diego,
California 92123
United States
Status
RECRUITING
|
RECRUITING | |
Facility
UCSF Medical Center-Mission Bay
San Francisco,
California 94158
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Children's Hospital Colorado
Aurora,
Colorado 80045
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
Denver,
Colorado 80218
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Connecticut Children's Medical Center
Hartford,
Connecticut 06106
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Yale University
New Haven,
Connecticut 06520
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Alfred I duPont Hospital for Children
Wilmington,
Delaware 19803
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
MedStar Georgetown University Hospital
Washington,
District of Columbia 20007
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Children's National Medical Center
Washington,
District of Columbia 20010
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Golisano Children's Hospital of Southwest Florida
Fort Myers,
Florida 33908
United States
Status
RECRUITING
|
RECRUITING | |
Facility
University of Florida Health Science Center - Gainesville
Gainesville,
Florida 32610
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood,
Florida 33021
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Nemours Children's Clinic-Jacksonville
Jacksonville,
Florida 32207
United States
Status
RECRUITING
|
RECRUITING | |
Facility
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami,
Florida 33136
United States
Status
ACTIVE_NOT_RECRUITING
Contact
N/A
|
ACTIVE_NOT_RECRUITING | |
Facility
Nicklaus Children's Hospital
Miami,
Florida 33155
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Arnold Palmer Hospital for Children
Orlando,
Florida 32806
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Nemours Children's Hospital
Orlando,
Florida 32827
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Sacred Heart Hospital
Pensacola,
Florida 32504
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Johns Hopkins All Children's Hospital
Saint Petersburg,
Florida 33701
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Tampa General Hospital
Tampa,
Florida 33606
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa,
Florida 33607
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Saint Mary's Medical Center
West Palm Beach,
Florida 33407
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Children's Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta,
Georgia 30329
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Atrium Health Navicent
Macon,
Georgia 31201
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Memorial Health University Medical Center
Savannah,
Georgia 31404
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Kapiolani Medical Center for Women and Children
Honolulu,
Hawaii 96826
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Saint Luke's Cancer Institute - Boise
Boise,
Idaho 83712
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Lurie Children's Hospital-Chicago
Chicago,
Illinois 60611
United States
Status
RECRUITING
|
RECRUITING | |
Facility
University of Illinois
Chicago,
Illinois 60612
United States
Status
RECRUITING
|
RECRUITING | |
Facility
University of Chicago Comprehensive Cancer Center
Chicago,
Illinois 60637
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Loyola University Medical Center
Maywood,
Illinois 60153
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Advocate Children's Hospital-Oak Lawn
Oak Lawn,
Illinois 60453
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Advocate Children's Hospital-Park Ridge
Park Ridge,
Illinois 60068
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Saint Jude Midwest Affiliate
Peoria,
Illinois 61637
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Southern Illinois University School of Medicine
Springfield,
Illinois 62702
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Riley Hospital for Children
Indianapolis,
Indiana 46202
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Ascension Saint Vincent Indianapolis Hospital
Indianapolis,
Indiana 46260
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Blank Children's Hospital
Des Moines,
Iowa 50309
United States
Status
RECRUITING
|
RECRUITING | |
Facility
University of Iowa/Holden Comprehensive Cancer Center
Iowa City,
Iowa 52242
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
University of Kentucky/Markey Cancer Center
Lexington,
Kentucky 40536
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Norton Children's Hospital
Louisville,
Kentucky 40202
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Children's Hospital New Orleans
New Orleans,
Louisiana 70118
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Ochsner Medical Center Jefferson
New Orleans,
Louisiana 70121
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Eastern Maine Medical Center
Bangor,
Maine 04401
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Maine Children's Cancer Program
Scarborough,
Maine 04074
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Sinai Hospital of Baltimore
Baltimore,
Maryland 21215
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore,
Maryland 21287
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Tufts Children's Hospital
Boston,
Massachusetts 02111
United States
Status
ACTIVE_NOT_RECRUITING
Contact
N/A
|
ACTIVE_NOT_RECRUITING | |
Facility
Dana-Farber Cancer Institute
Boston,
Massachusetts 02215
United States
Status
RECRUITING
|
RECRUITING | |
Facility
UMass Memorial Medical Center - University Campus
Worcester,
Massachusetts 01655
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
C S Mott Children's Hospital
Ann Arbor,
Michigan 48109
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Children's Hospital of Michigan
Detroit,
Michigan 48201
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Michigan State University Clinical Center
East Lansing,
Michigan 48824
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids,
Michigan 49503
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Bronson Methodist Hospital
Kalamazoo,
Michigan 49007
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Corewell Health Children's
Royal Oak,
Michigan 48073
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis,
Minnesota 55404
United States
Status
RECRUITING
|
RECRUITING | |
Facility
University of Minnesota/Masonic Cancer Center
Minneapolis,
Minnesota 55455
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Mayo Clinic in Rochester
Rochester,
Minnesota 55905
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
University of Mississippi Medical Center
Jackson,
Mississippi 39216
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
University of Missouri Children's Hospital
Columbia,
Missouri 65212
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Children's Mercy Hospitals and Clinics
Kansas City,
Missouri 64108
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Cardinal Glennon Children's Medical Center
Saint Louis,
Missouri 63104
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Washington University School of Medicine
Saint Louis,
Missouri 63110
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Mercy Hospital Saint Louis
Saint Louis,
Missouri 63141
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Children's Hospital and Medical Center of Omaha
Omaha,
Nebraska 68114
United States
Status
RECRUITING
|
RECRUITING | |
Facility
University of Nebraska Medical Center
Omaha,
Nebraska 68198
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
University Medical Center of Southern Nevada
Las Vegas,
Nevada 89102
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Sunrise Hospital and Medical Center
Las Vegas,
Nevada 89109
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas,
Nevada 89135
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Summerlin Hospital Medical Center
Las Vegas,
Nevada 89144
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Renown Regional Medical Center
Reno,
Nevada 89502
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon,
New Hampshire 03756
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Hackensack University Medical Center
Hackensack,
New Jersey 07601
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Morristown Medical Center
Morristown,
New Jersey 07960
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick,
New Jersey 08903
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Saint Joseph's Regional Medical Center
Paterson,
New Jersey 07503
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Albany Medical Center
Albany,
New York 12208
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Montefiore Medical Center - Moses Campus
Bronx,
New York 10467
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Roswell Park Cancer Institute
Buffalo,
New York 14263
United States
Status
RECRUITING
|
RECRUITING | |
Facility
The Steven and Alexandra Cohen Children's Medical Center of New York
New Hyde Park,
New York 11040
United States
Status
RECRUITING
|
RECRUITING | |
Facility
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York,
New York 10032
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Memorial Sloan Kettering Cancer Center
New York,
New York 10065
United States
Status
RECRUITING
|
RECRUITING | |
Facility
NYP/Weill Cornell Medical Center
New York,
New York 10065
United States
Status
RECRUITING
|
RECRUITING | |
Facility
University of Rochester
Rochester,
New York 14642
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Stony Brook University Medical Center
Stony Brook,
New York 11794
United States
Status
RECRUITING
|
RECRUITING | |
Facility
State University of New York Upstate Medical University
Syracuse,
New York 13210
United States
Status
RECRUITING
|
RECRUITING | |
Facility
New York Medical College
Valhalla,
New York 10595
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Mission Hospital
Asheville,
North Carolina 28801
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Carolinas Medical Center/Levine Cancer Institute
Charlotte,
North Carolina 28203
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Novant Health Presbyterian Medical Center
Charlotte,
North Carolina 28204
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Duke University Medical Center
Durham,
North Carolina 27710
United States
Status
RECRUITING
|
RECRUITING | |
Facility
East Carolina University
Greenville,
North Carolina 27834
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Wake Forest University Health Sciences
Winston-Salem,
North Carolina 27157
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Sanford Broadway Medical Center
Fargo,
North Dakota 58122
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Children's Hospital Medical Center of Akron
Akron,
Ohio 44308
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Cincinnati Children's Hospital Medical Center
Cincinnati,
Ohio 45229
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Rainbow Babies and Childrens Hospital
Cleveland,
Ohio 44106
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Cleveland Clinic Foundation
Cleveland,
Ohio 44195
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Nationwide Children's Hospital
Columbus,
Ohio 43205
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Dayton Children's Hospital
Dayton,
Ohio 45404
United States
Status
RECRUITING
|
RECRUITING | |
Facility
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo,
Ohio 43606
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
University of Oklahoma Health Sciences Center
Oklahoma City,
Oklahoma 73104
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Legacy Emanuel Children's Hospital
Portland,
Oregon 97227
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Oregon Health and Science University
Portland,
Oregon 97239
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Lehigh Valley Hospital-Cedar Crest
Allentown,
Pennsylvania 18103
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Geisinger Medical Center
Danville,
Pennsylvania 17822
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Penn State Children's Hospital
Hershey,
Pennsylvania 17033
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Children's Hospital of Philadelphia
Philadelphia,
Pennsylvania 19104
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Saint Christopher's Hospital for Children
Philadelphia,
Pennsylvania 19134
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Children's Hospital of Pittsburgh of UPMC
Pittsburgh,
Pennsylvania 15224
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Rhode Island Hospital
Providence,
Rhode Island 02903
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Medical University of South Carolina
Charleston,
South Carolina 29425
United States
Status
SUSPENDED
Contact
N/A
|
SUSPENDED | |
Facility
Prisma Health Richland Hospital
Columbia,
South Carolina 29203
United States
Status
RECRUITING
|
RECRUITING | |
Facility
BI-LO Charities Children's Cancer Center
Greenville,
South Carolina 29605
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Sanford USD Medical Center - Sioux Falls
Sioux Falls,
South Dakota 57117-5134
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
T C Thompson Children's Hospital
Chattanooga,
Tennessee 37403
United States
Status
ACTIVE_NOT_RECRUITING
Contact
N/A
|
ACTIVE_NOT_RECRUITING | |
Facility
East Tennessee Childrens Hospital
Knoxville,
Tennessee 37916
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Saint Jude Children's Research Hospital
Memphis,
Tennessee 38105
United States
Status
RECRUITING
|
RECRUITING | |
Facility
The Children's Hospital at TriStar Centennial
Nashville,
Tennessee 37203
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Vanderbilt University/Ingram Cancer Center
Nashville,
Tennessee 37232
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Texas Tech University Health Sciences Center-Amarillo
Amarillo,
Texas 79106
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Dell Children's Medical Center of Central Texas
Austin,
Texas 78723
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Driscoll Children's Hospital
Corpus Christi,
Texas 78411
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Medical City Dallas Hospital
Dallas,
Texas 75230
United States
Status
RECRUITING
|
RECRUITING | |
Facility
UT Southwestern/Simmons Cancer Center-Dallas
Dallas,
Texas 75390
United States
Status
RECRUITING
|
RECRUITING | |
Facility
El Paso Children's Hospital
El Paso,
Texas 79905
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Cook Children's Medical Center
Fort Worth,
Texas 76104
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston,
Texas 77030
United States
Status
RECRUITING
|
RECRUITING | |
Facility
M D Anderson Cancer Center
Houston,
Texas 77030
United States
Status
SUSPENDED
Contact
N/A
|
SUSPENDED | |
Facility
Covenant Children's Hospital
Lubbock,
Texas 79410
United States
Status
RECRUITING
|
RECRUITING | |
Facility
UMC Cancer Center / UMC Health System
Lubbock,
Texas 79415
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Children's Hospital of San Antonio
San Antonio,
Texas 78207
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Methodist Children's Hospital of South Texas
San Antonio,
Texas 78229
United States
Status
RECRUITING
|
RECRUITING | |
Facility
University of Texas Health Science Center at San Antonio
San Antonio,
Texas 78229
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Primary Children's Hospital
Salt Lake City,
Utah 84113
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
University of Virginia Cancer Center
Charlottesville,
Virginia 22908
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Inova Fairfax Hospital
Falls Church,
Virginia 22042
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Children's Hospital of The King's Daughters
Norfolk,
Virginia 23507
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Virginia Commonwealth University/Massey Cancer Center
Richmond,
Virginia 23298
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Carilion Children's
Roanoke,
Virginia 24014
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
Seattle Children's Hospital
Seattle,
Washington 98105
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Providence Sacred Heart Medical Center and Children's Hospital
Spokane,
Washington 99204
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Mary Bridge Children's Hospital and Health Center
Tacoma,
Washington 98405
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Madigan Army Medical Center
Tacoma,
Washington 98431
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
West Virginia University Charleston Division
Charleston,
West Virginia 25304
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Edwards Comprehensive Cancer Center
Huntington,
West Virginia 25701
United States
Status
RECRUITING
|
RECRUITING |
Facility | Status | Contact |
---|---|---|
Facility
University of Wisconsin Carbone Cancer Center - University Hospital
Madison,
Wisconsin 53792
United States
Status
RECRUITING
|
RECRUITING | |
Facility
Marshfield Medical Center-Marshfield
Marshfield,
Wisconsin 54449
United States
Status
SUSPENDED
Contact
N/A
|
SUSPENDED | |
Facility
Children's Hospital of Wisconsin
Milwaukee,
Wisconsin 53226
United States
Status
RECRUITING
|
RECRUITING |