BE CONNECTED Tailors Education and Support to Your Treatment

Mar . 19 . 2026

Kidney Cancer Association

This is a sponsored post provided by Exelixis.

If you’re reading this, you’re probably an information gatherer determined to learn everything you can about advanced kidney cancer. The old saying “Knowledge is power” is true, but educating yourself can be overwhelming.

Of course, your healthcare team should be your first stop for any questions. When you search on your own, it may help to find information that’s focused on your specific treatment rather than general information about your disease. A good place to start is seeing if your prescription medicine has a program that focuses specifically on your treatment journey.

For example, BE CONNECTED with CABOMETYX is a free educational support program you can sign up for if you or someone you are caring for is taking CABOMETYX^® (cabozantinib). This program covers topics relevant to the CABOMETYX treatment journey to help you stay on course. Please see approved Indications and Important Safety Information below.

Essentially, it’s an extra layer of educational support that is personalized to the CABOMETYX treatment journey, where you can learn about:

Dealing with possible side effects
How to get the answers you need from your healthcare team
Finding advocacy groups like the Kidney Cancer Association
Understanding why your dose may change
Tips for overall health & wellness

I think a program would be great to help people, people that are starting treatment, just to know more about the medicine, about side effects…. Absolutely it helps. I can’t imagine even going into something like that not having those questions answered.

— A person with advanced kidney cancer

BE CONNECTED is more than just information. You get different types of resources, including downloadable tools, patient experience videos, and education — all specific to the CABOMETYX treatment journey. All this without having to search, because BE CONNECTED delivers it directly to you.

Hear What a Healthcare Team Has to Say

If you’re wondering how BE CONNECTED may be able to help you, watch the video below. You can get the views of a healthcare team based on their experiences with the program.

Sign Up for Free Today

If you are prescribed CABOMETYX, we encourage you to check out BE CONNECTED for yourself. When you sign up, you can set your preferences on how you want to receive communications and, if it’s not right for you, you can cancel at any time — and there’s never a charge.

There are 3 ways to sign up for BE CONNECTED:

Click here
Text JOIN to (855) 716-6900
Scan the QR code below

This program is not a substitute for medical advice. Your healthcare team is your best resource for any questions about your condition or treatment.

INDICATIONS AND IMPORTANT SAFETY INFORMATION

What is CABOMETYX?

CABOMETYX is a prescription medicine used to treat:

People with kidney cancer (renal cell carcinoma). CABOMETYX may be used:
- In combination with nivolumab to treat people with renal cell carcinoma (RCC) that has spread (advanced RCC), and you have not already had treatment for your advanced RCC.
- Alone to treat people with advanced RCC.

It is not known if CABOMETYX is safe and effective in children.

What are the possible side effects of CABOMETYX?

CABOMETYX may cause serious side effects, including:

Bleeding (hemorrhage). CABOMETYX can cause severe bleeding that may lead to death. Tell your healthcare provider right away if you get any signs of bleeding during treatment with CABOMETYX, including:

coughing up blood or blood clots
vomiting blood or if your vomit looks like coffee grounds
red or black (looks like tar) stools
menstrual bleeding that is heavier than normal
any unusual or heavy bleeding

A tear in your stomach or intestinal wall (perforation) or an abnormal connection between 2 parts of your body (fistula). Tell your healthcare provider right away if you get tenderness or pain in your stomach area (abdomen) that is severe or that does not go away.

Blood clots, stroke, heart attack, and chest pain. Get emergency help right away for:

swelling or pain in your arms or legs
shortness of breath
feel lightheaded or faint
sweating more than usual
numbness or weakness of your face, arm, or leg, especially on one side of your body
sudden confusion, trouble speaking or understanding
sudden trouble seeing in one or both eyes
sudden trouble walking
dizziness, loss of balance or coordination
a sudden severe headache

High blood pressure (hypertension). Hypertension is common with CABOMETYX and sometimes can be severe. Your healthcare provider will check your blood pressure before starting CABOMETYX and regularly during treatment with CABOMETYX. If needed, your healthcare provider may prescribe medicine to treat your high blood pressure. Tell your healthcare provider if you develop severe headaches, nose bleeds, tiredness or confusion, vision changes, chest pain, trouble breathing, irregular heartbeat, or blood in your urine.

Heart problems. CABOMETYX can cause heart failure that may lead to death. Your healthcare provider may check your heart function before and during treatment with CABOMETYX. Tell your healthcare provider right away if you get any of the following signs and symptoms: feeling like your heart is pounding, racing, or beating irregularly; shortness of breath; swelling of your ankles or feet; feeling lightheaded; feeling tired.

Diarrhea. Diarrhea is common with CABOMETYX and can be severe. If needed, your healthcare provider may prescribe medicine to treat your diarrhea. Tell your healthcare provider right away if you have frequent loose, watery bowel movements.

A skin problem called hand-foot skin reaction. Hand-foot skin reactions are common with CABOMETYX and can be severe. Tell your healthcare provider right away if you have rashes, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet.

Liver problems. Liver problems may happen during treatment with CABOMETYX. When CABOMETYX is taken in combination with nivolumab, severe changes in liver function tests may happen more often than if you take CABOMETYX alone. Your healthcare provider will do blood tests to check your liver function before and during treatment with CABOMETYX.

Tell your healthcare provider right away if you develop symptoms of liver problems including: yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach area (abdomen), dark urine, bleeding or bruising more easily than normal.

Adrenal gland problems. Your healthcare provider will monitor you for this problem. Your healthcare provider may prescribe hormone replacement therapy or corticosteroid medicines if needed. Tell your healthcare provider right away if you develop any of the following signs or symptoms: extreme tiredness, dizziness or fainting, weakness, nausea, or vomiting.

Protein in your urine and possible kidney problems. Symptoms may include swelling in your hands, arms, legs, or feet. Your healthcare provider will check you for this problem during treatment with CABOMETYX.

Severe jaw bone problems (osteonecrosis). Your healthcare provider should examine your mouth before you start and during treatment with CABOMETYX. Tell your dentist that you are taking CABOMETYX. It is important for you to practice good mouth care during treatment with CABOMETYX. Tell your healthcare provider right away if you develop any symptoms of jaw problems, including: jaw pain, toothache, or sores on your gums.

Wound healing problems. Wound healing problems have happened in people who take CABOMETYX. Tell your healthcare provider if you plan to have any surgery before or during treatment with CABOMETYX.

You should stop taking CABOMETYX at least 3 weeks before planned surgery.
Your healthcare provider should tell you when you may start taking CABOMETYX again after surgery.

Reversible posterior leukoencephalopathy syndrome (RPLS). A condition called reversible posterior leukoencephalopathy syndrome can happen during treatment with CABOMETYX. Tell your healthcare provider right away if you have headaches, seizures, confusion, changes in vision, or problems thinking.

Change in thyroid function. CABOMETYX can cause changes in your thyroid function, including changes to thyroid hormone levels in your blood. Your healthcare provider will do blood tests to check your thyroid function before and during treatment with CABOMETYX.

Decreased calcium level in your blood (hypocalcemia). CABOMETYX can cause you to have a decreased amount of calcium in your blood. Your healthcare provider will do blood tests to check you for this problem and give you calcium if needed. Tell your healthcare provider right away if you get any of the following signs or symptoms:

muscle stiffness or muscle spasms
numbness or tingling in your fingers, toes, or around your mouth
seizures
sudden weight gain
swelling of your arms, hands, legs, and ankles

Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with CABOMETYX if you have certain side effects.

The most common side effects of CABOMETYX include:

tiredness
nausea and vomiting
constipation
decreased appetite
weight loss

The most common side effects of CABOMETYX when used with nivolumab include:

tiredness
mouth sores
rash
low thyroid hormone levels (hypothyroidism)
pain in muscles, bones, and joints
decreased appetite
nausea
changes in the way things taste
stomach area (abdominal) pain
cough
upper respiratory tract infection

CABOMETYX may cause fertility problems in females and males, which may affect your ability to have children. Talk to your healthcare provider if you have concerns about fertility.

These are not all of the possible side effects of CABOMETYX. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

If your healthcare provider prescribes CABOMETYX in combination with nivolumab, also read the Medication Guide that comes with nivolumab.

Before you take CABOMETYX, tell your healthcare provider about all of your medical conditions, including if you:

have had a liver problem other than liver cancer.
have a recent history of bleeding, including coughing up or vomiting blood, or black tarry stools.
have an open or healing wound.
have high blood pressure.
have a low calcium level in your blood (hypocalcemia).
plan to have any surgery, dental procedure, or have had a recent surgery. You should stop treatment with CABOMETYX at least 3 weeks before planned surgery.
are pregnant, or plan to become pregnant. CABOMETYX can harm your unborn baby.
- If you are able to become pregnant, your healthcare provider will check your pregnancy status before you start treatment with CABOMETYX.
- Females who are able to become pregnant should use effective birth control (contraception) during treatment and for 4 months after your last dose of CABOMETYX.
- Talk to your healthcare provider about birth control methods that may be right for you.
- If you become pregnant or think you are pregnant, tell your healthcare provider right away.
are breastfeeding or plan to breastfeed. It is not known if CABOMETYX passes into your breast milk. Do not breastfeed during treatment and for 4 months after your last dose of CABOMETYX.

Tell your healthcare provider about all the medicines you take, including prescription or over-the-counter medicines, vitamins, and herbal supplements. CABOMETYX and certain other medicines may affect each other, causing side effects.

What should I avoid while taking CABOMETYX?

Avoid drinking grapefruit juice, eating grapefruit, or taking supplements that contain grapefruit or St. John’s wort during treatment with CABOMETYX.

Please see the Patient Information in the full Prescribing Information. 