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Below are some of the research highlights from the 2022 American Urological Association’s annual meeting held on May 13-16 in New Orleans, Louisiana. 

Updated guidelines address new areas of renal mass management

The AUA updated their guidelines on managing potentially cancerous renal masses in adults. The new version expands upon and clarifies several areas of management including:

  • A multidisciplinary approach to genetic counseling
  • Adjuvant therapy addressed for the first time
  • Biopsy
  • Decisions about radical versus partial nephrectomy
  • More concrete guidance active surveillance and follow up

Since management approaches can vary widely, these guidelines could help treat people more consistently and better determine the risks and benefits of treatment approaches. Read more. Read the guidelines.

Racial disparities in kidney cancer survival

Black people with renal cell carcinoma had a higher risk of death compared with white people with kidney cancer, according to a study from the Johns Hopkins University School of Medicine in Baltimore, Maryland. This 8% difference was present after accounting for socioeconomic disparities such as having private insurance, income, presence of non-clear cell RCC, which is typically more aggressive and/or difficult to treat, and comorbidities. While these disparities were significant, among those diagnosed with metastatic RCC, systemic therapy was a greater predictor of survival, with more white patients receiving systemic therapy than Black patients. In addition to recognizing the structural differences that may account for differences in survival, the researchers are conducting a genomic analysis to see how biologic signatures may result in differences between Black and white kidney cancer patients too. Read more.

Better prediction of renal function after surgery

A radical nephrectomy to remove an entire kidney can put stress on and potentially decrease function in the remaining kidney. Researchers from the Cleveland Clinic found that kidney function as defined by baseline glomerular filtration rate was better predicted by a novel software to automatically measure renal function than a more traditional scan. Done before surgery, this could help determine whether a radical or partial nephrectomy is advisable. Read more.

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