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Votrient® (pazopanib) for Kidney Cancer

Votrient is a medication used to treat advanced kidney cancer in adults.

Dosage:  Your health care provider will discuss with you the dose of Votrient

How supplied:  200 mg tablets

Storage:   Room temperature.

Route of Administration:  Votrient is a tablet(s) taken by mouth

Schedule: once a day at the same time each day

How should I take Votrient?

  • Take it exactly the way your healthcare provider tells you
  • Must be taken on an empty stomach, at least 1 hour before or 2 hours after food
  • Do not crush Votrient tablets
  • If you miss a dose, take it as soon as you remember. Do not take if it is close (within 12 hours) to your next dose. Just take the next dose at your regular time. Do not take more than 1 dose of Votrient at a time.
  • If you vomit after taking a dose, do not take an additional dose.
  • If you think you have taken an extra dose of this medication, call your healthcare provider right away
  • Tell your healthcare provider if you plan to have surgery while taking VOTRIENT, as you will need to stop taking VOTRIENT at least 7 days before surgery 

Dietary restrictions: Do not eat grapefruit or drink grapefruit juice during treatment with Votrient. Grapefruit may increase the amount of Votrient in your body.

What important information I should know about Votrient?

  • Votrient can cause serious liver problems including death.
  • Evaluate liver function with a blood test before initiation of treatment and regularly during treatment

Your health care provider may prescribe a lower dose of Votrient or tell you to stop taking Votrient if you develop liver problems during treatment.

I should tell my healthcare provider if I:

  • have or have had liver problems
  • have high blood pressure
  • have heart problems or an irregular heartbeat
  • have a history of a stroke
  • have headaches, seizures, or vision problems
  • have coughed up blood in the last 6 months
  • had bleeding of your stomach or intestines in the last 6 months
  • have a history of a tear (perforation) in your stomach or intestine, or an abdominal connection between two parts of your gastrointestinal tract (fistula)
  • have had blood clots in a vein or in the lung
  • have thyroid problems
  • had recent surgery (within the last 7 days) or are going to have surgery
  • have any other medical conditions
  • are or plan to become pregnant. Votrient can harm your unborn baby. You should not become pregnant while you are taking Votrient.
  • Male and females taking Votrient should use effective birth control during treatment with Votrient and for at least 2 weeks after your last dose of Votrient.
  • are breast-feeding or plan to breast-feed. It is not known if Votrient passes into your breast milk. You and your healthcare provider should decide if you will take Votrient or breast-feed. You should not do both.

Call your healthcare provider before you start any new medications and tell them at each visit about all the medications you take including prescription and non-prescription medicine, vitamins, and herbal supplements. Votrient may affect the way other medicines work and other medicines may affect how Votrient works. For example:

  • certain antibiotics
  • some drugs used to treat HIV
  • medications used to treat depression
  • drugs used to treat irregular heart beats
  • drugs used to treat high cholesterol levels such as simvastatin
  • take a medication that reduce stomach acid (e.g. esomeprazole)

Ask your healthcare provider if you are not sure if your medicine is one that is listed above.

Know the medicines you take. Keep a list of them and show it to your health-care provider and pharmacist when you get a new medicine.

Common side effects of Votrient include:

  • diarrhea
  • high blood pressure
  • nausea or vomiting
  • loss of appetite
  • change in hair color
  • feeling tired
  • decreased weight
  • sores on hands and feet
  • tumor pain
  • stomach pain
  • headache

What are other possible side effects of Votrient?

Votrient may cause serious side effects including:

  • liver problems (see above)
  • high blood pressure  
  • thyroid problems   
  • protein in your urine
  • irregular or fast heartbeat or fainting
  • heart failure
  • heart attack or stroke: chest pain or pressure, pain in your arms, back, neck or jaw, shortness of breath, numbness or weakness on one side of your body, trouble talking, headache, or dizziness.
  • blood clots
  • bleeding problems: unusual bleeding, bruising, wounds that do not heal.
  • tear in your stomach or intestinal wall (perforation) or bleeding: pain, swelling in your stomach-area, vomiting blood, and black sticky stools.
  • lung problems. Tell your healthcare provider right away if you get a cough that will not go away or shortness of breath
  • Call your doctor right away if you experience:
    • headache
    • blindness or change in vision
    • seizures
    • weakness
    • confusion
    • high blood pressure
    • problems thinking
  • infection
  • collapsed lung (pneumothorax)

These are not all of the possible side effects of Votrient. Tell your healthcare provider if you have any side effects that bother you or that do not go away. Call your doctor for medical advice about side effects. For more information, ask your healthcare provider or pharmacist. 

Patient Support Line 1-888-669-6682
M-F 8:30am- 5:00 PM ET

Adapted from the VOTRIENT (pazopanib) Patient Support site Novartis, November 2020

KCA disclaimer statement: You should rely primarily upon your doctor for medical information.