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Votrient® (pazopanib) for Kidney Cancer

Votrient is a medication used to treat advanced kidney cancer in adults.

Dosage:  800 mg once a day

How supplied:  200 mg tablets

Storage:   Room temperature. 

Route of Administration:  Votrient is a tablet taken by mouth

Schedule:  4 tablets (800 mg) once a day at the same time each day

How should I take Votrient?

  • Take it exactly the way your healthcare provider tells you
  • Must be taken on an empty stomach, at least 1 hour before or 2 hours after food
  • Do not crush Votrient tablets
  • If you miss a dose, take it as soon as you remember. Do not take if it is close (within 12 hours) to your next dose. Just take the next dose at your regular time. Do not take more than 1 dose of Votrient at a time.
  • If you vomit after taking a dose, do not take an additional dose.
  • If you think you have taken an extra dose of this medication, call your healthcare provider right away 
  • Tell your healthcare provider if you plan to have surgery while taking VOTRIENT, as you will need to stop taking VOTRIENT at least 7 days before surgery  

Dietary restrictions: – Do not eat grapefruit or drink grapefruit juice during treatment with Votrient. Grapefruit may increase the amount of Votrient in your body.

What is the most important information I should know about Votrient?

  • Votrient can cause serious liver problems including death. 
  • Evaluate liver function with a blood test before initiation of treatment and regularly during treatment 

Tell your healthcare provider right away if you have any of these signs of liver problems: 

  • yellowing of your skin or the whites of your eyes (jaundice)
  • dark urine
  • tiredness 
  • nausea or vomiting
  • loss of appetite
  • pain on the right side of your stomach area (abdomen)
  • bruise easily

Your health care provider may prescribe a lower dose of Votrient or tell you to stop taking Votrient if you develop liver problems during treatment

I should tell my healthcare provider if I: 

  • have or have had liver problems
  • have high blood pressure
  • have heart problems or an irregular heartbeat including QT prolongation
  • have a history of a stroke
  • have headaches, seizures, or vision problems
  • have coughed up blood in the last 6 months
  • had bleeding of your stomach or intestines in the last 6 months
  • have a history of a tear (perforation) in your stomach or intestine, or an abdominal connection between two parts of your gastrointestinal tract (fistula)
  • have had blood clots in a vein or in the lung
  • have thyroid problems
  • had recent surgery (within the last 7 days) or are going to have surgery
  • have any other medical conditions
  • are or plan to become pregnant. Votrient can harm your unborn baby. You should not become pregnant while you are taking Votrient. 
  • Male and females taking Votrient should use effective birth control during treatment with Votrient and for at least 2 weeks after your last dose of Votrient.
  • are breast-feeding or plan to breast-feed. It is not known if Votrient passes into your breast milk. You and your healthcare provider should decide if you will take Votrient or breast-feed. You should not do both.

Tell your healthcare provider at each visit about all the medications you take including prescription and non-prescription medicine, vitamins, and herbal supplements. Votrient may affect the way other medicines work and other medicines may affect how Votrient works. For example:

  • certain antibiotic (used to treat infections)
  • some drugs used to treat HIV
  • some drugs used to treat depression
  • certain medications used to treat depression
  • drugs used to treat irregular heart beats
  • drugs used to treat high cholesterol levels such as simvastatin
  • take a medication that reduce stomach acid (e.g. esomeprazole)
  • if you drink grapefruit juice

Ask your healthcare provider if you are not sure if your medicine is one that is listed above.

Know the medicines you take. Keep a list of them and show it to your health-care provider and pharmacist when you get a new medicine.

What are the possible side effects of Votrient?

Votrient may cause serious side effects including: 

  • liver problems (see above)
  • high blood pressue
  • irregular or fast heartbeat or fainting
  • heart failure
  • heart attack or stroke: chest pain or pressure, pain in your arms, back, neck or jaw, shortness of breath, numbness or weakness on one side of your body, trouble talking, headache, or dizziness.
  • blood clots
  • thrombotic microangiopathy (TMA) including thrombotic thrombocytopenia purpura (TTP) and hemolytic uremic syndrome (HUS).  TMA is a condition involving blood clots.  
  • bleeding problems: unusual bleeding, bruising, wounds that do not heal.
  • tear in your stomach or intestinal wall (perforation) or bleeding: pain, swelling in your stomach-area, vomiting blood, and black sticky stools.
  • lung problems. Tell your healthcare provider right away if you get a cough that will not go away or shortness of breath
  • Reversible Posterior Leukoencephalopathy Syndrome (RPLS)  can happen while taking Votrient. Call your doctor right away if you experience:

– headache

– blindness or change in vision

– seizures

– weakness

– confusion

– high blood pressure

– problems thinking

  • thyroid problems
  • protein in your urine
  • serious infections
  • collapsed lung (pneumothorax)   

Common side effects of Votrient include:

  • diarrhea
  • change in hair color
  • nausea or vomiting
  • loss of appetite
  • feeling tired
  • hypertension
  • decreased weight
  • tumor pain
  • stomach pain
  • headache
  • taste changes
  • trouble breathing
  • change in skin color
  • sores on hands and feet

These are not all of the possible side effects of Votrient. Tell your healthcare provider if you have any side effects that bother you or that do not go away.   

Call your doctor for medical advice about side effects. For more information, ask your healthcare provider or pharmacist.  

Patient Assistance Program:  Novartis Oncology Universal Co-pay Program

1-877-577-7756

Adapted from the VOTRIENT (pazopanib) package insert. Novartis, September 2018 

KCA disclaimer statement:  you should rely primarily upon your doctor for medical information.