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Torisel® (temserolimus) for kidney cancer

Torisel is a medication used to treat advanced kidney cancer in adults

Dosage:  25 mg

Route of administration:  Intravenous infusion

Schedule:  Once a week

Pfizer Oncology Together:  This is a financial services program from Pfizer. To enroll, speak to your healthcare provider, call 1-877-744-5675 or go to www.torisel.com and  https://www.pfizeroncologytogether.com

Dietary restriction:

  • Grapefruit juice or St. John’s Wort may increase the amount of Torisel in your body and should be avoided
  • Your health care practitioner may ask you not to eat prior to getting blood work

I should tell my healthcare provider if I:

  • have kidney or liver function problems (other than cancer)
  • take steroids such as prednisone
  • have a history of diabetes
  • have a history of high cholesterol or high triglycerides
  • have a wound that is not healing
  • plan to
    • have surgery
    • visit the dentist
    • get a vaccination (no live vaccines)
  • have any bleeding problems
  • take any other medical conditions
  • are pregnant or plan to become pregnant. Torisel can harm your unborn baby. You should not become pregnant while you are taking Torisel. Talk to your doctor about birth control methods to prevent pregnancy while you are being treated or have recently been treated with Torisel. A reliable form of birth control should be used during treatment and for 3 months after the last dose of Torisel
  • males with female partners of reproductive potential to use effective contraception during treatment with Torisel and for 3 months after receiving the last dose
  • are breast-feeding or plan to breast-feed. It is not known if Torisel passes into your breast milk. Breast feeding should be avoided while being treated with Torisel and for 3 weeks after the last dose of Torisel.

Medications that can interfere with Torisel

Some medicines can interfere with the breakdown or metabolism of Torisel:

  • You should discuss all medicines you take with your oncologist
  • Be sure to inform your physician if you are taking any of the following: Protease inhibitors, anti-epileptic medicines including carbamazepine, phenytoin, and barbiturates, St. John’s Wort, rifampicin, rifabutin, nefazodone or selective serotonin re-uptake inhibitors used to treat depression, antibiotics, or antifungal medicines used to treat infections

Vaccinations:

Vaccinations may be less effective while being treated with Torisel.

You should avoid live vaccines, and close contact with those who have received live vaccines while being treated with Torisel.

What are the possible side effects of Torisel? 

Torisel may cause serious side effects including:

  • Allergic reactions may occur during infusions. These may include, but are not limited to:  flushing, rash, hives, chest pain or tightness, shortness of breath, low blood pressure, back pain, loss of consciousness. This reaction can be serious, including anaphylaxis. If any of these happen while receiving your infusion, tell your nurse immediately
  • an increased risk of infection
  • a change in your normal lung function resulting in a new or change in an existing cough
  • increased blood sugar
  • kidney failure
  • a tear in your stomach or intestinal wall (perforation) resulting in pain, vomiting blood and/or black tarry stools
  • abnormal wound healing
  • bleeding in your brain resulting in headaches, blurred vision or a change in mental status
  • Allergic reactions may occur during infusions. These may include, but are not limited to:  flushing, rash, hives, chest pain or tightness, shortness of breath, low blood pressure, back pain, loss of consciousness. If any of these happen while receiving your infusion, tell your nurse immediately

Common side effects of Torisel include:

  • rash
  • weakness/fatigue (asthenia)
  • mouth sores (mucositis)
  • nausea
  • swelling or fluid retention (edema)
  • loss of appetite (anorexia)
  • an increase in your blood levels of triglycerides and cholesterol
  • elevated blood sugar (glucose) levels
  • abnormal liver function

These are not all of the possible side effects of Torisel. Tell your healthcare provider if you have any side effects that bother you or that do not go away.  

Call your doctor for medical advice about side effects. For more information, ask your healthcare provider or pharmacist.

Resources: https://www.pfizeroncologytogether.com

Adapted from the Torisel® (temsirolimus) package insert.  Pfizer. March 2018

KCA disclaimer statement:  you should rely primarily upon your doctor for medical information.

www.kidneycancer.org