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Avastin® (bevacizumab) for Advanced Kidney Cancer

Avastin is a medication used in combination with interferon alfa to treat advanced kidney cancer in adults 

Dosage:   10mg/kg
Route of Administration:  Intravenous infusion
Schedule:   Every 2 weeks
Dietary restrictions:  None

I should tell my healthcare provider if I: 

  • have high blood pressure
  • have kidney problems, other than cancer
  • plan to have surgery or have had surgery in the past four weeks.
  • have a wound or sore that has not healed
  • have any bleeding problems
  • have a history of a stomach ulcer
  • have a history of coughing up blood
  • have had a recent stroke or heart attack

For women; tell your doctor if you:

  • are pregnant or planning to become pregnant.  Avastin can harm an unborn baby and you should not seek pregnancy during treatment or for at least 6 months after the last dose of Avastin. Talk to your doctor about birth control methods to prevent pregnancy while you are being treated or have recently been treated with Avastin.  Avastin may also have an impact of fertility as it can cause the ovaries to stop working.
  • are breast-feeding or plan to breast-feed. It is not known if Avastin passes into the breast milk, therefore breast feeding should be avoided while on Avastin

Tell your healthcare provider at each visit about all the medications you take including prescription and non-prescription medicine, vitamins, and supplements. Avastin may interfere with the way other medicines work and other medicines may interfere with how Avastin works. 

Especially tell your doctor if you are taking any other anti-cancer medication.

Know the medicines you take.  Keep a current list of them to show your doctors and pharmacist whenever you get a new medication.

What are the possible side effects of Avastin?

Common Side effects include:

  • high blood pressure
  • headache
  • nose bleeds
  • runny nose
  • changes in tear production
  • dry skin
  • rash
  • protein in the urine (you may be asked to periodically give a urine sample to monitor for this side effect)
  • back pain
  • rectal bleeding
  • change in taste

These are not all of the possible side effects of Avastin. Tell your healthcare provider if you have any side effects that bother you or that do not go away. 

Talk to your health care team for more information or advice about side effects. 

Avastin may cause serious side effects including:

  • gastrointestinal (GI) perforation; (development of a hole in the stomach or intestine).  Common signs of perforation include unusual abdominal pain, nausea, vomiting, constipation or fever.  These symptoms, should they occur, should be reported immediately to your health care team.  
  • fistula (development of a tract or connection from one bodily organ such as the intestine to a bodily cavity or another organ such as the skin or bladder).
  • stroke
  • bleeding
  • blood clot
  • heart attack
  • delayed wound healing

Call your doctor right away if you get:

  • bleeding from the rectum or vomit blood
  • chest pain
  • shortness of breath
  • severe headache 
  • loss of vision
  • confusion
  • difficulty with word finding or speaking
  • loss of balance

General information about Avastin: This patient Information sheet summarizes the most important information about Avastin. If you would like more information, talk with your healthcare team. You can ask your doctor for information about Avastin that is written for healthcare professionals.  

Patient Assistance Program:  Genentech Access Solutions

Resources:  Genentech, Inc. 1-866-422-2377  

Web address:  www.genentech-access.com

Adapted from the Avastin package insert.  Genentech, Inc. June 2019

KCA disclaimer statement:  you should rely primarily upon your doctor for medical information.

www.kidneycancer.org